1. What binds to antithrombin II sites?
    Heparin which is an indirect thrombin inhibitor.
  2. What is the antidote for Heparin?
    Protamine sulfate
  3. Why is there a toxicity with NSAID and SSRI when taking Coumadin (Warfarin)?
    NSAIDs increase the risk of bleeding
  4. How does Coumadin (Warfarin) work?
    Inhibits the action of Vitamin K. Anticoagulant medication.
  5. How's Coumadin (Warfarin) toxicity treated with?
    It is reversed by Vitamin K.
  6. How does Ticlid (Ticlopidine) work?
    Inhibits platelet aggregation. Antiplatelet medication.
  7. What does Alteplase (activase) do?
    It's a thrombolytic drug, whis is used to dissolve existing clots. Goal is to quickly restore blood flow to the tissue served by the blocked vessel. Converts plasminogen to plasma.
  8. What does Amicar (aminocaproic Acid) and oral contraceptives are warned about?
    Hemostatic medication. Prescribed in excessive bleeding due to clots being prematurely dissolved. Hypercoagulation with estrogens and oral contraceptives.
  9. How does Amicar (aminocaproic acid) work?
    Hemostatic medication. Prescribed in excessive bleeding due to clots being prematurely dissolved. Inactivates plasminogen.
  10. What is the prothrombin time for Warfarin (INR)?
    12-15 seconds is normal; 2 - 4.5 got INR (post tx)
  11. Hemostatics and thrombolytic disease are indicated with Amicar (aminocparoic acid)?
    Because Amicar tends to stabilize clots, it should be used cautiously in pts with hx of the disease.
  12. What is Calan?
    Ca channel blocker. Inhibits inflow of Ca. Slows conduction velocity, lowers BP, and CA dilation.
  13. What is Quinidine sulfate (Quinidex)?
    Blocks Sodium channels. Broad spectrum antidysrhythmic.
  14. What is Inderal (propanolol)?
    non-selective Beta blocker. Angina, HTN, migraine headaches and prophylaxis of MI.
  15. What is Amiodarone - Cardorone?
    Potassium channel blocker. Resistant ventricular tachycardia and atrial dysrhythmia in HF pts.
  16. What is the drug interaction for Amiodarone and quinidine sulfate?
    Amiodarone (Cardorone) increases its level and thus the risk of heart block.
  17. Impotence with which drug?
    Propanolol (Inderal) diminished sex drive and impotence.
  18. Which drug produces pneumonia like syndrome?
    Amiodarone (Calderone) Potassium channel blocker.
  19. Which drug inhibits inflow of Ca?
    Calan which is a Ca channel Blocker. Slow conduction velocity, lowers BP, and CA dilation.
  20. Which drug blocks inactive sodium channels?
    Amiodarone (Cardorone) block both inactivated sodium and potassium channels. Used for resistant ventricular tachycardia and atrial dysrhythmias in HF pts.
  21. What is heart block?
    Area of conduction in the mycoardium; may be partial or complete; classified as first, second, or third degree.
  22. What is atrial or ventricular tachycardia?
    rapid heartbeat greater than 100 bpm in adults; ventricular tachycardia is more serious than atrial tachycardia.
  23. What is sinus bradycardia?
    slow heartbeat, less than 60 bpm, may require a pacemaker.
  24. What is atrial or ventricular flutter and/or fibrillation?
    very rapid, uncoordinated beats; atrial may require tx but is not usually fatal; ventricular flutter or fibrillation requires immediate tx.
  25. What is premature atrial or premature ventricular contractions (PVCs)?
    An extra beat often originating from a source other than the SA node; not normally serious unless it occurs in high frequency.
Card Set
Anticoagulants and Dysrhythmias