Path VI

What are pale areas of in neuronal cytoplasm from dispersion of Nissle Substance (rER)?

Destruction of axon and myelin sheath d/t trauma or toxic injury=

Accumulation of glial cells around damaged neurons=

Softening/liquefaction of nervous tissue d/t necrosis of neurons and glial cells=

What is the total absence of the entire brain?

Failure of telencephalic cavity separation + Failure to close rostral neural tube (severe cases with central proboscis and cyclopia)?

Cerebral Aplasia is commone in: 2

Protrusion of fluid filled meninges (often associated with treatment of griseofulvin in the queen)?

Meningoceles are most commonly seen in: 2

What disorder, causes the brain surface to be smooth except for slight grooves in which the meningeal vessels are situated?

Lissencephaly is commonly in seen in:

In what animals does hydraencephaly =>absence of the cerebral hemispheres and no ependymal lining? 2

What are the different types of hydrocephalus (common in brachycephalic breeds and aged animals)? 3

What congenital disorder develops as a consequence of a periductal gliosis of the aqueduct of sylvius?

What develops as a consequence of obstructed flow due to an accumulation of exudates (there is no malformation of cranium)?

Acquired hydracephalus can develop as a sequelae to what diseases? 5

Cysts in white matter of cerebal hemisphere=

In what animals do you see Porencepahly (cysts in white matter of the cerebral hemisphere)? 3

In what animals is cerebellar hypoplasia most commonly observed? 3

Tubular Caviation of the spinal cord=

What is a tubular cavitation (syrinx) of the spinal cord which extends over several segments, common in weimaraner breed (normal posture is crouched)?

What is a simple dilation of the central canal of the spinal cord?

What is absence of the dorsal portions of the vertebrae?

Spina Bifida is commonly seen in: 2

What is the result of failure of dehiscence of the neural crest from the surface ectoderm?

In what diseases do you see intracytoplasmic neuronal vacuolization? 4

What is primary demyelination? Secondary?

What are the earliest lesions seen in Abiotrophy (premature programmed neuronal cell loss)?

Where can prion disease be detected in animals? 4

What is bovine spongiform encephalopathy attributed to?

What genetic disorder involves partially disassembled compounds accumulating within the lysosomes => neuronal and glial cell necrosis?

Deficiency of the catabolic enzyme galactocerbroside-B-galactosidase and PAS-positive globoid type MO's are characteristic of?

Globoid Cell Leukodystrophy is common in: 2

What => foamy appearance of necrotic neuronal tissue?

What is leukomalacia?
Poliomalacia?
Encephalomalacia?
Myelomalacia?
Encephalomyelomalacia?

When is focal malacia usually seen?