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Metabolic X syndrome includes which 3 components
- Glucose intolerance
- Hyperlipidemia
- Hypertension
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Zucker Fatty Rat is a model for what disease
Genetic Obesity (leptin receptor mutation)
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SHROB is a model for what disease?
Control?
- Genetic obesity, metabolic disease
- Kol is the lean littermate
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DIO is a model for what disease
- Nutritional obesity- normal leptin
- metabolic syndrome X
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Osborne-Mendel is a study for what disease?
- Nutritional diabetes
- spontaneous tumors
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BBDP is a model for what disease?
Control?
- BBDP/Wor for Type I diabetes
- BBDR/Wor
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ZDF rat is a model for what disease
ZDF-Type 2 Diabetes Mellitus
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What is the gender difference with ZDF rats?
Male ZDF develop diabetes in a different diet, females need more fat and lower protein
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Cohen Diabetic Rat is a model for what disease?
Type II diabetes
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Goto-Kakizaki (GK) rat is a model for what disease
Type II diabetes, ESRD
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Otsuka Long-Evans Tokushima Fatty Rat (OLETF) is a model for which disease?
Type II diabetes
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Wistar Fatty Rat is a model for which disease?
Type II diabetes
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Injection of STZ in the neonate causes what?
Type II diabetes (n-STZ)
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Injection of STZ in the adult rat causes what?
Type I diabetes
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SHR is a model for what disease?
Control?
- Spontaneous hypertension
- WKY
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Genetically Hypertensive Rat (GH) are a model for what disease?
Spontaneous Hypertension
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Fawn Hooded Hypersensitive rat (FHH) is a model for what disease?
Spontaneous hypertension
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Lyon Hypertensive rat is a model for what disease?
Spontaneous hypertension without hyperinsulinemia
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Sabra Hypertension Prone (SBH) is a model for what disease
Spontaneous hypertension, salt sensitive and testeosterone dependent
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Milan Hypertensive (MHS) is model for what disease?
Spontaneous hypertension
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Dahl Salt sensitive (SS/Jr) is a model for what disease
Salt sensitive hypertension
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Young SS/Jr is a model for what disease
renin hypertension
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Genetically Epilepsy Prone Rats (GEPR/3 and GEPR/9) are a model for what disease?
generalized genetic epilepsy
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WAG/Rij is a model for what disease
Genetic petit mal or absence epilepsy
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Genetic absence epilepsy rat from Strasboug (GAERS) is a model for what disease?
Genetic absensence epilepsy
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When giving a DA rat complete Freunds adjuvant +MBP, what happens?
Experimental Autoimmune Encephalomyelitis Multiple Sclerosis
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When giving a LEW rat incomplete Freunds adjuvant +MBP what happens?
EAE
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What are the 3 compounds that can be given to a rat to induce Parkinsons
rotenone, MPTP, and 6-hydroxy dopamine
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ZDF and BB/Wor have been studied for what besides diabetes?
Peripheral neuropathy
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Lobound Wistar (LW) rat is a model for what disease
Prostate cancer
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Noble rat is a model for what disease?
Prostate cancer
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COP and WF are models for what disease and how do they differ?
COP is a negative model, dominant resistant gene to mammary carcinogenesis
WF- mammary cancer suceptible
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ZSF1 rats are a model for what disease?
End Stage renal disease
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Han:SPRD Cy/Cy is a model for what disease?
Autosomal Dominant Polycystic Kidney Disease
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Brattleboro rats are a model to what disease?
Diabetes Insipidis, neurogenic
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M520/DI is a model for what disese
diabetes Insipidius
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SHPSP is mode for waht disease
cerebrovascular lesions, proteinuria
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SHHF is a model for what disease
Spontaneous Hypertensive Heart Failure Rat is a model for type 2 diabetes, CHF, and Obesity
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JCR:LA-cp is a model for what disease?
cp corpulent, cardiovascular disease
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Name 5 compounds that can be injected to create a model for autoimmune rheumatoid arthritis
- Type II collagen
- complete Freunds adjuvant
- Incomplete Freunds adjuvant
- Pristane
- Streptococcol wall (LEW)
- DA is very susceptible, BB (DR)
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