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Which class of drug has good placental penetration?
NRTI
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Which class of drug does not undergo CYP450 elimination?
NRTI
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Which class of drug is renally eliminated?
NRTI
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What class of drug is Efavirenz ,which should be taken on an empty stomach as (high fat meals increase the aborption)
NNRTI
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What class of drug is Rilpivirine, the drug that needs >500 calorie meal for adequate absorption?
NNRTI
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Which class of drug uses extensive CYP450 metabolism and has a long half-life (up to 30-50 hours)
NNRTI
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Which class of drug is a substrate of P-gp and CYP-3A4, has high first pass metabolism and low bioavailability, and included Atazanavir which needs acid for absorption?
PIs
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Which class of drugs is Enfuvirtide in?
fusion inhibitors
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Which class of drug is Maraviroc, which is a substrate of P-gp and CYP450?
CCR5 inhibitors
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Which class of drug is Raltegravir, a drug that is eliminated by glucuronidation.
Integrase inhibitors
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What happens when NNRTIs are given with statins?
NNRTIs decrease the concentration of statins therefore may need to be more aggressive with statin doses
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What happens when Tenofovir is given with Atazanavir?
Atazanavir concentration is decreased and should always be boosted with ritonavir if given together
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What happens when PIs are given with rifampin or St. John's Wort?
They both decrease the concentration of the PI and are contraindicated
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What kind of interaction do PIs have with lovastatin/simvastatin?
PIs increase the concentration of lovastatin/simvastatin and are contraindicated with PIs
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What is the maximum daily dose of omeprazole in patients taking PIs?
- 20mg per day
- avoid PPIs in experienced pts
- always boost with RTV
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Which statins are preferred for a patient taking PIs?
pravastatin or atorvastatin b/c PI's increase the concentration of statins
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