Home
Flashcards
Preview
PK
Home
Get App
Take Quiz
Create
Describe the 2 separate processess of dialysis.
1. Diffusion = uses a concentration gradent (high to low)
2. Ultrafiltration = water being pulled off; the greater the surface area, the higher the efficiency of the filter (flow rate for dialysate)
What are the drug characteristics that affect dialysis removal?
molecular weight
water/lipid solubility
plasma protein binding
volume of distribution
inherent clearance (route and rate)
What size drug molecules tend to be readily eliminated by dialysis?
small drug molecules (< 500 daltons)
What size drugs have a decreased ability to pass through the semi-permeable membrane in low flux filters?
moderate molecular mass (500-1000 daltons)
What type of drugs still have sufficient dialysis clearance to require post-dialysis replacement doses?
moderate molecular mass (500-1000 daltons)
What type of drugs require high-flux filters for removal?
large molecules (>1000 daltons)
A drug that tends to remain in the blood has what kind of solubility?
lipid solubility
What happens to drugs that have a high degree of water solubility?
They tend to partition into water-based dialysis fluid
What type of drug molecules are able to pass through the pores in a semi-permeable membrane?
Unbound
What type of drugs are prone to better dialysis clearance?
Drugs that are NOT highly plasma protein-bound have a high free fraction of drug in the blood.
Where are medications with a high Vd mostly located?
At tissue binding sites and not in the blood
Are drugs with a low Vd more or less easily removed by dialysis?
More easily removed
Determine if the following drugs are more likely or less likely to be removed by dialysis:
Drug 1: Vd > 2L/kg
Drug 2: Vd < 1L/kg
Drug 1
: less likely (not in the blood)
Drug 2
: more likely
If a drug is primarily eliminated by the kidney, will it have a higher or lower likelihood of being removed by dialysis?
higher
What are the 3 most common dialysis techniques?
HD
: hemodialysis
CAPD
: continuous ambulatory peritoneal dialysis
CVVH
: continuous venovenous hemofiltration
Author
ch.tyrrell
ID
150718
Card Set
PK
Description
Dialysis
Updated
2012-04-28T20:11:50Z
Show Answers
Home
Flashcards
Preview