What does the immune system do?
fights off the foreign invaders that are constantly attacking the body
Also fights against its own cells that can become cancerous
The system can also attack itself and cause autoimmune diseases or immune-mediated diseases
What do Immunosupressant drugs decrease or prevent?
- an immune response
- suppresses the immune system
What are immunosuppressant drugs used for?
Used for rejection therapy after an organ transplant
Used for the treatment of rheumatoid arthritis
What do immunosuppressant drugs do?
They suppress certain lymphocyte (T-cells) cell lines
What does Cyclosporine intract with
Has a profound interaction with many drugs GRAPEFRUIT JUICE of any form
What does Cyclosporine do ?
Increases serum levels
WHat are cyclosporines used for?
- Used for the prevention of organ rejection
- Can be used for arthritis, psoriasis, IBD
What are Imuran and Cellcept used for?
Used for prophylaxis for organ rejection
what can Imuran and Cellcept be given in combo with
May be given in combo with cyclosporine and corticosteroids
How are the s/e of Imuran and Cellcept?
Side effects can be numerous
What are some side effects of CYCLOSPORINE?
- moderate hypertension
- Neurotoxicity including tremors
- Hepatotoxicity with cholelithiasis and hyperbilirubiemia Nephrotoxicity
- Gingival hyperplasia
what do you assess for cyclosporine?
- Check renal function and urinary function
- Liver function, is there jaundice, edema or ascites
- Check cardiofunction, any history of dysrythmias, hypertension
- CNS baseline, seizure history
- Respiratory assessment
what do you do if WBC drop when taking Cyclosporine?
if WBC’s drop below 3K, stop medication
When do you check labs when giving immunnosuppression agents?
before, during and after therapy
What form of immunossuppression meds do you try to give 1st?
Oral before IM
to decrease risk of infection that is common with IM injections
WHen should antifungals be given?
Oral antifungals should be given together with immunosupressants to treat oral candidiasis which is common
what should pt's do if they find any early signs of infection or illness?
how long after using immunosuppressants should women use birth control?
}Women on immunosupressants- use birth control for up to 12 weeks after therapy is completed
what should pt's taking oral cyclosorines do to avoid GI upset?
take with CHOCOLATE MILK or with MEALS!!
what kind of med is METHOTREXATE considered?
What kind of CA is methotrexate used for?
Used for solid tumors in the breast, head, neck, lungs,
for lymphocytic leukemia
other CA what is mehotrexate starting to be used for?
- can be used for rheumatoid arthritis, SLE
- has immunosuppressant activity-