Quiz 10

Anti-fibrinolytic agent
Treatment of cyclic heavy menstrual bleeding.
Synthetic lysine amino acid derivative; preserves and stabilizes fibrin's matrix structure

Ovulation stimulants

Used to treat ovarian failure and male infertility
Appears to increase pituitary output of gonadotropin
Important Ovulation agent to know

Ovulation agent used for prepubertal cryptochidism, hypogonadism, ovulation stimulation

Final follicular maturation and ovulation induction

Polypeptides with Chorionic gonadotropin activity

Polypeptide with Chorionic gonadotropin activity
Injection
Primary hypothalamic amenorrhea

Polypeptide with Chorionic gonadotropin activity
Nasal solution
Endometriosis and central precocious puberty

Two forms of Histrelin acetate

Polypeptide with chorionic gonadotropin activity
injection
for central precocious puberty

Polypeptide with chorionic gonadotropin activity
Implant
Palliative treatment of advanced prostate cancer by decreasing testosterone levels to castrate concentration following the first week of use

Gonadotropins

Gonadotropin for ovulation induction and follicular stimulation

Gonadotropin used for polycystic ovary syndrome and follicular stimulation

Gonadotropin indicated for the stimulation of spermatogenesis in men and ovulation induction and follicular stimulation in women

Gonadotropin-rleasing hormone antagonists indicated for treatment of infertility

Recombinant form of human luteinizing hormone
Injection (SubQ)
To be used with Gonal-F
Used for the stimulation of follicular development in infertile hypogonadotropic hypogonal women with profound LH deficiency
Strict Criteria

IM injection of a synthetic decapeptide
Given over a course of 6 months
Used for the treatment of advanced prostate cancer to achieve medical castration, also for severe bone pain
MoA: direct and competitive blocker of gonadotropin releasing hormone
Allergic reactions and QT prolongation possible

Short acting testosterone products from the form testosterone

Short acting testosterone aqueous suspension

Short acting testosterone SC pellets

Short acting testosterone transdermal

Short acting testosterone buccal mucoadhesive adheres to the gum tissue above the incisors

Short acting testosterone topical solution for hypogonadism

Testosterone Long-acting products in oil base for injection in prodrug form

Used for endometriosis, fibrocystic breast disease, hereditary angioedema
Inhibits pituitary gonadotropins

Steroids for BPH

Steroid for BPH
Used for Benign prostatic hyperplasia, androgenic alopecia
Inhibits steroid 5alpha-reductase preventing testosterone conversion to 5alpha-dihydrotestosterone

Steroid for BPH
Only for treating BPH
Inhibits steroid 5alpha-reductase preventing testosterone conversion to 5alpha-dihydrotestosterone

Non-steroidals for BPH

Nonsteroid for BPH
Selective blockade of smooth muscle post-synaptic alpha1-adrenergic receptors
Metabolism by CYP3A4

Nonsteroidal for BPH
Selective blockade/antagonism of smooth muscle post-synaptic alpha1a-adrenergic receptor
Less orthostatic hypotension
CYP3A4

Steroids used for anabolic activity

Steroid for anabolic activity
Used adjunctive to promote weight gain after surgery, chonic infections, severe trauma, HIV wasting syndrome

Steroid used for anabolic activity
Used for anemias causing blood marrow to produce more blood cells

Steroid used for anabolic activity
Used for anemias of renal insufficiency
For patients on dialysis

Drugs used for Hereditary Angioedema

Used for hereditary angioedema

Protein products derived from human plasma C1 esterase inhbitiors for hereditary angioedema which regulates clotting and inflammatory reactions that lead to local tissue swelling

Protein product derived from human plasma C1 esterase inhibitor used prophylactically

Protein product derived from human plasma C1 esterase inhibitors for acute attacks

Used for hereditory angioedema acute attacks
Human plasma kallkrein inhibitor
SubQ injection
Watch for anaphylaxis
MoA: exerts effects by directly inhibiting kallikrein therby reducing excessive bradykinin production and symptoms of localized swelling, inflammation, and pain

Used for Hereditory Angioedema for acute attacks
selective bradykinin B2 receptor antagonist which prevents incontrollable vascular permeability and angioedema

Non-Steroid product used for anemia
Analogue of the drug Thalidomide
Used for Transfusion dependent anemia due to low or intermediate 1 risk myelodysplastic syndrome
Unknown MoA
TERATOGENIC! Requires pregnancy test

Uterine active agents used as abortifacents

Abortifacent
Black box warning because sepsis may occur
Binds to progesteron and glucocorticoid receptors with no estrogenic activity and prevents DNA transcription
CYP3A4

Abortifacients that stimulate uterine contrations used in conjunction with surgical methods such as saline-injections or suction abortion
Prostaglandins

Uterine-active agents
Cervical Ripening
Used to induce labor in conjunction with oxytocin
Stimulates uterine contractions

Uterine-active agents
Used to induce labor by IV
a natural pituitary hormone that increases uterine contractions

Agents for post-partum or post-abortal bleeding

Agent for post-partum(abortal) bleeding
Partial antagonist/agonist of alpha-adrenergic dopaminergic or tryptaminergic receptor of uterine tissue increasing uterine contractions and decreasing bleeding
Injection

Agent for post-partum(abortal) bleeding
Tablet or Injection
Will see new Mommys get

Uterine agent
Injection for the management of pre-term labor
Beta2-receptor agonist that decreases uterine smooth muscle contractions

What are used to treat osteoporosis by slowing the formation and dissolution of calcium phosphate crystals?

Bisphosphonates

Bisphosphonates that come in the form of tablets only

Bisphosphonates that comes in the form of parenteral injections or tablets

Bisphosphonate parenteral injection only

Bisphosphonate that follows a monthly dosing schedule but must also take calcium and this drug can really put the hurt on the stomach

Bisphosphonate product for parental injection has two forms
Zometa treats hypercalcemia due to malignancy
Reclast treats osteoprorosis and Paget's disease for IV administration once a year

Bisphonate
Oral tablet
Postmenopausal osteoporosis
Renal clearnace linear to creatinine clearnace
New form only requiring once a month dosing

New treatment of Osteoporosis in men and women
rDNA origin injection from recombinanat human parathyroid hormone by stimulating new bone formation
Produced by Escherichia coli

Treatment of Osteoporosis of postmenopausal women with osteoporosis at high risk for fracture
Given every six months
IgG2 monoclonal antibody
147 kDa protein from CHO cells
Side effects: hypocalcemia, infections, pancreatitis

Treatment of Osteoporosis
Prevention of skeletal-related events such as pathological fracture, spinal cord compression or radiation to the bone in patients with bone metastases from solid tumors

Calcimimetic
Treatment for secondary hyperparathyroidism dialysis patient with chronic kidney disease, hypercalcemia secondary to parathyroid carcinoma
Metabolized by CYP3A4, CYP2D6, CYP1A2
Take with food or after meal (Watch for hypocalcemia)
Increases sensitivity of the Ca2+ sensing receptor on parathyroid gland chief cells that regulat the production of PTH

Major endogenous mineralocorticoid

Major endogenous glucocorticoid

Used to treat addison's diesease caused by primary adrenocortical insufficiency and secondary adrenocortical insufficiency (inadequate ACTH secretion)

Diagnostic test of pituitary adrenocorticotropic function reduces cartisol and corticosterone production by inhibiting the 11beta-hydroxylation reaction in the adrenal cortex. Diagnostic test

No topical absorption for small areas for Cushings diesease

Adrenocorticol Steroids
Prevents the conversion of cholesterol to pregnenolone
For cushing syndrome, postmenopausal patients with advance breast and prostate carcinoma

Abortifacent RU-486 with indication for Cushings
Treatment of Cushing's Syndrome
Antagonists of one of the body's two cortisol receptors and progesterone receptor
Used in treating psychosis and depression associated with Cushings

Pituitary Hormones
Indicated for: diagnostic testing of adrenal function, nonsuppurativ thyroiditis, hypercalcemia assocated with cancer, acute multiple sclerosis, among other uses

More potent and less allergenic than the natural product for pituitary hormones

Glucocorticoid product indicated for primary and secondary adrenal insufficiency, collagen diseases, dermatoligc diseases, allergic states, ophthalmic inflammation, respiratory disease, hematolic disorders, neoplastic disease such as leukemias, edematous states, GI disease, acute moutain sickness
Tablets and Injections

Adrenocortical steroids

Mineralcorticoid product
For primary or secondary adreanl insufficiency, management of severe orthostatic hypotension

Immun response modulator
Rhemuatoid arthitis
Inhibits dihydroorotate dehydrogenase
Not for pregnancy or desired pregnancy
Contraception require
Prodrug
Inhitits CYP2C9

Growth Hormone Products for growth failure associate with chronic renal insufficiency, growth failure, cachexia, Turner syndrome, Somatoropin defieciency

Recombiinant Inuline like Growth factor-1
For treatment of growth failure in children with severe primary like growth factor

Posterior Pituitary Hormone products

Posterior Pituitary Hormone products
Injection indicated for diabetes insipidus, abdominal distention, anti-diuretic hormone activity

Posterior Pituitary Hormone products
Nasal Spray for diabetes insipidus, antidiuretic hormone activity

Posterior Pituitary Hormone products
tablets, injections, nasal spray
Nocturnal enuresis, diabetes insipidus, hemophilia A, von willebrands disease

Posterior Pituitary Hormone products
Injection
Acromegaly, tumors, GI fistula, diarrheal states, hypoglycemia due to excess insulin

Hormone analog for Acromegaly
For long-term treatment of acromegalic patients who have had an inadequate response to or cannot be treate with surgery and or radiotherapy
May cause gallstones, hypo or hyperglycemia, and bradycardia
reduction of GH or IGF1 levels

Treatment of Tyrosinemia Type 1
Orphan Drug
rare pediatic disease causing progressive liver failure, hepatocellular carcinoma, coagylopathy, painful neurological crises and renal tubular dysfunction

Injection and nasal spray
Isolated from salmon
Calcitonin suppressor resportipin bone by inhibiting the actity of osteoclast
Postmenopausal osteoporosis, Paget's disease, hypercalcemia

Miscellaneous agent used in cancer related hypercalcemia

Miscellaneous agent used in homocystinuria due to elevated blood levels acts as a methyl donor to produce methionine

Recombinant DNA product indicated for women 5 years postmenopausal with low bone mass index
Must coadminister with calcium and vitamin D

Miscellaneous agent
Management of Nephropathic cystinosis, cystine depleting agent

Urea Cycle Disorder caused by enzyme deficiencies treatment

Treatment of hyperprolactinemia

Treatment of hyperprolactinemia
low dose in diabetics

New drug to treat euvolemic hyponatremia
Euvolemic hyponatremia
antagonist of arginine vasopressin
Cases excretion of free water
Highly protein bound

Agent covered in CV-6
Hypervolemic and euvolemic hyponatremia patients with HF, cirrhosis and inappropriate antidiuretic hormone secretion
Oral selective vasopressin-receptor antagoinst increase water excretion in the kidney without concurrent soidum loss
Metabolized by CYP4A and is a pglycoprotein substrate