Quiz 10

  1. Anti-fibrinolytic agent
    Treatment of cyclic heavy menstrual bleeding.
    Synthetic lysine amino acid derivative; preserves and stabilizes fibrin's matrix structure
    Tranexamic acid, Lysteda
  2. Ovulation stimulants
    • Clomiphene Citrate (Clomid, Milophene, Serophene)
    • Chorionic gonadotropin (Chorex-5, Profasi, Pregnyl)
    • Chorionic gonadotropin alpha (Ovidrel)
  3. Used to treat ovarian failure and male infertility
    Appears to increase pituitary output of gonadotropin
    Important Ovulation agent to know
    Clomiphene Citrate (Clomid, Milophene, Serophene)
  4. Ovulation agent used for prepubertal cryptochidism, hypogonadism, ovulation stimulation
    Chorionic gonadotropin (Chorex-5, Profasi, Pregnyl)
  5. Final follicular maturation and ovulation induction
    Chorionic gonadotropin alpha (Ovidrel)
  6. Polypeptides with Chorionic gonadotropin activity
    • Gonadorelin acetate (Lutrepulse)
    • Nafarelin acetate (Synarel)
    • Histrelin acetate (Supprelin)
    • *Remember acetate
  7. Polypeptide with Chorionic gonadotropin activity
    Primary hypothalamic amenorrhea
    Gonadorelin acetate (Lutrepulse)
  8. Polypeptide with Chorionic gonadotropin activity
    Nasal solution
    Endometriosis and central precocious puberty
    Nafarelin acetate (Synarel)
  9. Two forms of Histrelin acetate
    • Supprelin- injection
    • Vantus- implant
  10. Polypeptide with chorionic gonadotropin activity
    for central precocious puberty
    Histrelin acetate (Supprelin)
  11. Polypeptide with chorionic gonadotropin activity
    Palliative treatment of advanced prostate cancer by decreasing testosterone levels to castrate concentration following the first week of use
    Histrelin acetate (Vantus)
  12. Gonadotropins
    • Urofollitropin (Fertinex)
    • Follitropin alpha (Gonal-F)
    • Follitropin beta (Follistim)
    • Menotropins (Pergonal)
    • *Have tropin in them
  13. Gonadotropin for ovulation induction and follicular stimulation
    • Follitropin alpha (Gonal-F)
    • Follitropin beta (Follistim)
    • Menotropins (Pergonal) in women
  14. Gonadotropin used for polycystic ovary syndrome and follicular stimulation
    Urofollitropin (Fertinex)
  15. Gonadotropin indicated for the stimulation of spermatogenesis in men and ovulation induction and follicular stimulation in women
    Menotropins (Pergonal)
  16. Gonadotropin-rleasing hormone antagonists indicated for treatment of infertility
    • (Antagon)
    • Cetrorelix acetate (Cetrotide)
  17. Recombinant form of human luteinizing hormone
    Injection (SubQ)
    To be used with Gonal-F
    Used for the stimulation of follicular development in infertile hypogonadotropic hypogonal women with profound LH deficiency
    Strict Criteria
    Lutropin alfa (Luveris)
  18. IM injection of a synthetic decapeptide
    Given over a course of 6 months
    Used for the treatment of advanced prostate cancer to achieve medical castration, also for severe bone pain
    MoA: direct and competitive blocker of gonadotropin releasing hormone
    Allergic reactions and QT prolongation possible
    Abarelix (Plenaxis)
  19. Short acting testosterone products from the form testosterone
    Tesamone, Testopel, Testoderm, Androderm, Striant, Axirone, Fortesta
  20. Short acting testosterone aqueous suspension
  21. Short acting testosterone SC pellets
  22. Short acting testosterone transdermal
    Testoderm, Androderm
  23. Short acting testosterone buccal mucoadhesive adheres to the gum tissue above the incisors
  24. Short acting testosterone topical solution for hypogonadism
    Axiron, Fortesta
  25. Testosterone Long-acting products in oil base for injection in prodrug form
    • Testosterone Enanthate (Andro LA)
    • Testosterone Cypionate (Depo-Testosterone)
  26. Used for endometriosis, fibrocystic breast disease, hereditary angioedema
    Inhibits pituitary gonadotropins
    Danazol (Danocrine)
  27. Steroids for BPH
    • Finasteride (Propecia, Proscar)
    • Dustasteride (Avodart)
  28. Steroid for BPH
    Used for Benign prostatic hyperplasia, androgenic alopecia
    Inhibits steroid 5alpha-reductase preventing testosterone conversion to 5alpha-dihydrotestosterone
    Finasteride (Propecia, Proscar)
  29. Steroid for BPH
    Only for treating BPH
    Inhibits steroid 5alpha-reductase preventing testosterone conversion to 5alpha-dihydrotestosterone
    Dutasteride (Avodart)
  30. Non-steroidals for BPH
    • Alfuzosin HCl (Uroxatral)
    • Silodosin (Rapaflo)
  31. Nonsteroid for BPH
    Selective blockade of smooth muscle post-synaptic alpha1-adrenergic receptors
    Metabolism by CYP3A4
    Alfuzosin HCl (Uroxatral)
  32. Nonsteroidal for BPH
    Selective blockade/antagonism of smooth muscle post-synaptic alpha1a-adrenergic receptor
    Less orthostatic hypotension
    Silodosin (Rapaflo)
  33. Steroids used for anabolic activity
    • Oxandrolone (Oxandrin)
    • Oxymtholone (Anadrol-50)
    • Oxandrolone decanoate (Deca-Durabolin)
  34. Steroid for anabolic activity
    Used adjunctive to promote weight gain after surgery, chonic infections, severe trauma, HIV wasting syndrome
    Oxandrolone (Oxandrin)
  35. Steroid used for anabolic activity
    Used for anemias causing blood marrow to produce more blood cells
    Oxymethalone (Anadrol-50)
  36. Steroid used for anabolic activity
    Used for anemias of renal insufficiency
    For patients on dialysis
    Oxandrolone decanoate (Deca-Durabolin)
  37. Drugs used for Hereditary Angioedema
    • Stanoxozolol (Winstrol)
    • Danazol
    • Cinryne
    • Berinert
    • Ecallantide (Kalbitor)
    • Icatibant (Firazyr)
  38. Used for hereditary angioedema
    Stanoxozolol (Winstrol)
  39. Protein products derived from human plasma C1 esterase inhbitiors for hereditary angioedema which regulates clotting and inflammatory reactions that lead to local tissue swelling
    • Cinryne
    • Berinert
  40. Protein product derived from human plasma C1 esterase inhibitor used prophylactically
  41. Protein product derived from human plasma C1 esterase inhibitors for acute attacks
  42. Used for hereditory angioedema acute attacks
    Human plasma kallkrein inhibitor
    SubQ injection
    Watch for anaphylaxis
    MoA: exerts effects by directly inhibiting kallikrein therby reducing excessive bradykinin production and symptoms of localized swelling, inflammation, and pain
    Ecallaantide (Kalbitor)
  43. Used for Hereditory Angioedema for acute attacks
    selective bradykinin B2 receptor antagonist which prevents incontrollable vascular permeability and angioedema
    Icatibant (Firazyr)
  44. Non-Steroid product used for anemia
    Analogue of the drug Thalidomide
    Used for Transfusion dependent anemia due to low or intermediate 1 risk myelodysplastic syndrome
    Unknown MoA
    TERATOGENIC! Requires pregnancy test
    Lenalidomide (Revlimid)
  45. Uterine active agents used as abortifacents
    • RU-486 Mifepristone (Mifeprex)
    • Dinoprostone (Prepidil)
    • Carboprost Tromethamine (Hemabate)
  46. Abortifacent
    Black box warning because sepsis may occur
    Binds to progesteron and glucocorticoid receptors with no estrogenic activity and prevents DNA transcription
    RU-486 Mifepristone (Mifeprex)
  47. Abortifacients that stimulate uterine contrations used in conjunction with surgical methods such as saline-injections or suction abortion
    • Dinoprestone (Prepidil)
    • Carboprost Tromethamine (Hemabate)
  48. Uterine-active agents
    Cervical Ripening
    Used to induce labor in conjunction with oxytocin
    Stimulates uterine contractions
    Dinoprostone (Prepidil)
  49. Uterine-active agents
    Used to induce labor by IV
    a natural pituitary hormone that increases uterine contractions
  50. Agents for post-partum or post-abortal bleeding
    • Ergoovine maleate (Ergotrate)
    • Methylergonovine maleate (Methergine)
    • *Maleate
  51. Agent for post-partum(abortal) bleeding
    Partial antagonist/agonist of alpha-adrenergic dopaminergic or tryptaminergic receptor of uterine tissue increasing uterine contractions and decreasing bleeding
    Ergonovine maleate (Ergotrate)
  52. Agent for post-partum(abortal) bleeding
    Tablet or Injection
    Will see new Mommys get
    Methylegonovine maleate (Methergine)
  53. Uterine agent
    Injection for the management of pre-term labor
    Beta2-receptor agonist that decreases uterine smooth muscle contractions
    Ritodrine (Yutopar)
  54. What are used to treat osteoporosis by slowing the formation and dissolution of calcium phosphate crystals?
  55. Bisphosphonates
    • Etidronate (Didronel)
    • Pamidronate (Aredia)
    • Alendronate (Fosamax)
    • Tiludronate sodium (Skelid)
    • Risedronate sodium (Actonel)
    • Zoledronic acide (Zometa, Reclast)
    • Ibandronate sodium (Boniva)
  56. Bisphosphonates that come in the form of tablets only
    • Alendronate (Fosamax)
    • Tiludronate sodium (Skelid)
  57. Bisphosphonates that comes in the form of parenteral injections or tablets
    Etidronate (Didronel)
  58. Bisphosphonate parenteral injection only
    Pamidronate (Aredia)
  59. Bisphosphonate that follows a monthly dosing schedule but must also take calcium and this drug can really put the hurt on the stomach
    Risedronate sodium (Actonel)
  60. Bisphosphonate product for parental injection has two forms
    Zometa treats hypercalcemia due to malignancy
    Reclast treats osteoprorosis and Paget's disease for IV administration once a year
    Zoledronic acid
  61. Bisphonate
    Oral tablet
    Postmenopausal osteoporosis
    Renal clearnace linear to creatinine clearnace
    New form only requiring once a month dosing
    Ibandronate Sodium (Boniva)
  62. New treatment of Osteoporosis in men and women
    rDNA origin injection from recombinanat human parathyroid hormone by stimulating new bone formation
    Produced by Escherichia coli
    Teriparatide (Forteo)
  63. Treatment of Osteoporosis of postmenopausal women with osteoporosis at high risk for fracture
    Given every six months
    IgG2 monoclonal antibody
    147 kDa protein from CHO cells
    Side effects: hypocalcemia, infections, pancreatitis
    Denosumab (Prolia)
  64. Treatment of Osteoporosis
    Prevention of skeletal-related events such as pathological fracture, spinal cord compression or radiation to the bone in patients with bone metastases from solid tumors
    Denosumab (Xgeva)
  65. Calcimimetic
    Treatment for secondary hyperparathyroidism dialysis patient with chronic kidney disease, hypercalcemia secondary to parathyroid carcinoma
    Metabolized by CYP3A4, CYP2D6, CYP1A2
    Take with food or after meal (Watch for hypocalcemia)
    Increases sensitivity of the Ca2+ sensing receptor on parathyroid gland chief cells that regulat the production of PTH
    Cinacalcet HCl (Sensipar)
  66. Major endogenous mineralocorticoid
  67. Major endogenous glucocorticoid
  68. Used to treat addison's diesease caused by primary adrenocortical insufficiency and secondary adrenocortical insufficiency (inadequate ACTH secretion)
    Cortisol or Hydrocortisone
  69. Diagnostic test of pituitary adrenocorticotropic function reduces cartisol and corticosterone production by inhibiting the 11beta-hydroxylation reaction in the adrenal cortex. Diagnostic test
    Metopirone (Metyrapone)
  70. No topical absorption for small areas for Cushings diesease
  71. Adrenocorticol Steroids
    Prevents the conversion of cholesterol to pregnenolone
    For cushing syndrome, postmenopausal patients with advance breast and prostate carcinoma
    Aminogluethimide (Cytadren)
  72. Abortifacent RU-486 with indication for Cushings
    Treatment of Cushing's Syndrome
    Antagonists of one of the body's two cortisol receptors and progesterone receptor
    Used in treating psychosis and depression associated with Cushings
    Mifepristone (Corlux)
  73. Pituitary Hormones
    Indicated for: diagnostic testing of adrenal function, nonsuppurativ thyroiditis, hypercalcemia assocated with cancer, acute multiple sclerosis, among other uses
    • Corticotropin (ACTH)
    • Cosyntropin (Cortosyn)
  74. More potent and less allergenic than the natural product for pituitary hormones
    Cosyntropin (Cortosyn)
  75. Glucocorticoid product indicated for primary and secondary adrenal insufficiency, collagen diseases, dermatoligc diseases, allergic states, ophthalmic inflammation, respiratory disease, hematolic disorders, neoplastic disease such as leukemias, edematous states, GI disease, acute moutain sickness
    Tablets and Injections
    Cortisone (Cortone Acetate)
  76. Adrenocortical steroids
    • Betamethasone (and other forms)
    • Hydrocortisone (and other forms)
    • Dexamethasone (and other forms)
    • Prednisone
    • Prednisolone (and other forms)
    • Methylprednisolone (and other forms)
    • Triamcinolone (and other forms)
  77. Mineralcorticoid product
    For primary or secondary adreanl insufficiency, management of severe orthostatic hypotension
    Fludrocortisone Acetate
  78. Immun response modulator
    Rhemuatoid arthitis
    Inhibits dihydroorotate dehydrogenase
    Not for pregnancy or desired pregnancy
    Contraception require
    Inhitits CYP2C9
    Leflunomide (Arava)
  79. Growth Hormone Products for growth failure associate with chronic renal insufficiency, growth failure, cachexia, Turner syndrome, Somatoropin defieciency
    • Sometrem (Protropin)
    • Somatropin (Humatrope, Nutropin)
  80. Recombiinant Inuline like Growth factor-1
    For treatment of growth failure in children with severe primary like growth factor
    Mesasermin (Increlex)
  81. Posterior Pituitary Hormone products
    • Vasopressin
    • Lypressin
    • Desmopressin acetate
    • Octreotide acetate
  82. Posterior Pituitary Hormone products
    Injection indicated for diabetes insipidus, abdominal distention, anti-diuretic hormone activity
    Vasopressin (pitressin)
  83. Posterior Pituitary Hormone products
    Nasal Spray for diabetes insipidus, antidiuretic hormone activity
    Lypressin (Diapid)
  84. Posterior Pituitary Hormone products
    tablets, injections, nasal spray
    Nocturnal enuresis, diabetes insipidus, hemophilia A, von willebrands disease
    Desmopressin acetate (DDVAP)
  85. Posterior Pituitary Hormone products
    Acromegaly, tumors, GI fistula, diarrheal states, hypoglycemia due to excess insulin
    Octreotide acetate (Sandostatin)
  86. Hormone analog for Acromegaly
    For long-term treatment of acromegalic patients who have had an inadequate response to or cannot be treate with surgery and or radiotherapy
    May cause gallstones, hypo or hyperglycemia, and bradycardia
    reduction of GH or IGF1 levels
    Somatuline Depot (Lanreotide)
  87. Treatment of Tyrosinemia Type 1
    Orphan Drug
    rare pediatic disease causing progressive liver failure, hepatocellular carcinoma, coagylopathy, painful neurological crises and renal tubular dysfunction
    Nitisinone (Orfadin)
  88. Injection and nasal spray
    Isolated from salmon
    Calcitonin suppressor resportipin bone by inhibiting the actity of osteoclast
    Postmenopausal osteoporosis, Paget's disease, hypercalcemia
    Calcitonin-Samon (Miacalcin)
  89. Miscellaneous agent used in cancer related hypercalcemia
    Gallium Nitrate (Ganite)
  90. Miscellaneous agent used in homocystinuria due to elevated blood levels acts as a methyl donor to produce methionine
    Betaine anhydrous (Cystadane)
  91. Recombinant DNA product indicated for women 5 years postmenopausal with low bone mass index
    Must coadminister with calcium and vitamin D
  92. Miscellaneous agent
    Management of Nephropathic cystinosis, cystine depleting agent
    Cysteamine bitartrate
  93. Urea Cycle Disorder caused by enzyme deficiencies treatment
    • Sodium phenylbutyrate (Buphenyl)
    • Sodium Benzoate
    • Sodium Phenylacetate
  94. Treatment of hyperprolactinemia
    Cabergoline (Dostinex)
  95. Treatment of hyperprolactinemia
    low dose in diabetics
    Bromocriptine mesylate (Parlodel)
  96. New drug to treat euvolemic hyponatremia
    Euvolemic hyponatremia
    antagonist of arginine vasopressin
    Cases excretion of free water
    Highly protein bound
    Conivaptan HCl (Vaprisol)
  97. Agent covered in CV-6
    Hypervolemic and euvolemic hyponatremia patients with HF, cirrhosis and inappropriate antidiuretic hormone secretion
    Oral selective vasopressin-receptor antagoinst increase water excretion in the kidney without concurrent soidum loss
    Metabolized by CYP4A and is a pglycoprotein substrate
    Tolvaptan (Samsca)
Card Set
Quiz 10
Quiz 10