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What isPemphigus Vulgaris?
- Autoimmune dz against desmosomes
- Acantholysis
- Onset 40-60yo
- Can be fatal if not treated (immunosuppressive drugs)
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What is Bullous Pemphigoid?
- Autoimmune dz against basement membrane proteins (hemidesmosomes)
- Often follows other skin eruption, like erythema multiforme
- Onset > 60yo
- Tx with systemic prednisone
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What is Epidermolysis bulla?
- Congenital dz with friable skin that responds to minimal trauma with break down, bulla formation and ulceration.
- N-sign
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Steven’s Johnson syndrome
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Hyperpigmented palmar creases, gingival and nails
Addison's dz
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Argyria: silver consumption
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Neurofibromatosis: cafe au lait spot with smooth border
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McCune Albright syndrome: Cafe au lait spot with "coast of Maine" border
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- Vitiligo: defect in melanocytes to produce melanin
- Symmetric presentation
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Hypoethetic or anethetic hypopigmented macules and plaques.
Leprosy (Hansen's dz)
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- Pellagra: hypopigmented, scaly lesions
- Cause by niacin/tryptophan deficiency
- Diarrhea
- Dementia
- Death
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Pityriasis alba: self-limiting (possibly allergic)
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