Epinephrine

  1. Class
    Sympathetic Agonist
  2. Description
    Naturally occurring catecholamine with both Alpha and Beta adrenergic stimulant effects
  3. Mechanism of Action
    • Acts directly on Alpha and Beta receptors. Beta is more profound.
    • Increases HR, cardiac contractile forces, electrical activity in myocardium, SVR, BP, automaticity
  4. Onset of Action
    • Onset: <2 min
    • Peak: <5 min
    • Duration: 5-10 min
    • Half-life: 5 min
  5. Indications
    • Cardiac arrest
    • Severe Anaphalaxyis
    • Severe reactive airway disease
    • Bronchial asthma
    • Allergic reactions
    • Symptomatic Bradycardia refractory to Atropine
  6. Contraindications
    • Epi 1:10,000 is contraindicated in pts that don't require extensive Cardiopulmonary resuscitative efforts
    • Use Epi 1:1,000 for simple allergic reactions
  7. Precautions
    • Protect from light
    • deactivated by alkaline solutions (flush line often)
    • Increases myocardial O2 demand, can cause ischemia
    • Monitor HR, BP, EKG
  8. Side Effects
    • Palpitations
    • Headaches
    • Tremulousness
    • Dizziness
    • Nausea
    • Vomiting
  9. Adult Dose
    • Cardiac Arrest: 1mg of 1:10,000 every 3-5 min IV
    • Anaphylaxis or Asthma: 0.3-0.5mg of 1:10,000 IV or 0.3-0.5mg of 1:1,000 IM/SQ
  10. Pedi Dose
    Cardiac Arrest: 0.01mg/kg of 1:10,000 every 3-5 min IV
  11. Max Dose
    None for cardiac arrest
  12. Route of Administration
    IV/IO/IM/SQ
  13. How Supplied
    • Vials
    • Bristajet
Author
Kgren
ID
148459
Card Set
Epinephrine
Description
Epinephrine
Updated