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Class
Sympathetic Agonist
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Description
Naturally occurring catecholamine with both Alpha and Beta adrenergic stimulant effects
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Mechanism of Action
- Acts directly on Alpha and Beta receptors. Beta is more profound.
- Increases HR, cardiac contractile forces, electrical activity in myocardium, SVR, BP, automaticity
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Onset of Action
- Onset: <2 min
- Peak: <5 min
- Duration: 5-10 min
- Half-life: 5 min
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Indications
- Cardiac arrest
- Severe Anaphalaxyis
- Severe reactive airway disease
- Bronchial asthma
- Allergic reactions
- Symptomatic Bradycardia refractory to Atropine
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Contraindications
- Epi 1:10,000 is contraindicated in pts that don't require extensive Cardiopulmonary resuscitative efforts
- Use Epi 1:1,000 for simple allergic reactions
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Precautions
- Protect from light
- deactivated by alkaline solutions (flush line often)
- Increases myocardial O2 demand, can cause ischemia
- Monitor HR, BP, EKG
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Side Effects
- Palpitations
- Headaches
- Tremulousness
- Dizziness
- Nausea
- Vomiting
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Adult Dose
- Cardiac Arrest: 1mg of 1:10,000 every 3-5 min IV
- Anaphylaxis or Asthma: 0.3-0.5mg of 1:10,000 IV or 0.3-0.5mg of 1:1,000 IM/SQ
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Pedi Dose
Cardiac Arrest: 0.01mg/kg of 1:10,000 every 3-5 min IV
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Max Dose
None for cardiac arrest
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Route of Administration
IV/IO/IM/SQ
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