Renal Dose Adjustments

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Why are SCr values now standardized?
- Decrease variability among laboratories
- Improve reliability of eGFR results
What weight should be used to calculate the CG CrCl equation?
- Actual
- Unless the patient is 30% greater than IBW, then use Adjusted body weight
What is a requirement of the patient's renal function when calculating CrCl?

Stable renal function
What are some limitations of using CG CrCl?
- Overestimates renal function
- Not re-expressed with standardized SCr values
- Use in elderly patients- should we round SCr to 1.0?
- Use in obese patients- not sure what weight to use
What are some clinical pearls of CrCl?
- Used most frequently in practice
- Preferred method for drug dosing
What are some limitations for MDRD?
- Use of SCr
- Underestimates GFR
- Not validated for drug dosing
- Not tested in elderly patients, low weight patients or some ethnic groups
- Less accurate at higher GFRs (Reason we say > 60 instead of an exact number)
What are the clinical pearls for MDRD?
- Population screening tool
- Reported with most lab data
- Pysicians constantly referring to this to dose medications
- Can be used for dosing if adjusted for body surface area
What are some limitations of CKD-EPI?
- Complex equation
- Not validated in children, pregnant women, and some ethnic subgroups
- Not adapted into clinical practice
- Not validated for drug dosing
What is a clinical pearl of CKD-EPI?

More accurate with eGFR > 60 ml/min/1.73 m2
What are the units for weight and heigh in the Salazar-Corcoran equation?
- Kg
- Meters
In what patient population is the salazar-corcoran equation most commonly used?

Morbidly obese patients
What are some limitations of the salazar-corcoran equation?
- Only for morbidly obese patients
- Not commonly used in practice
What is a clinical pearl of the salazar-corcoran equation?

Uses fat-free body mass

Author

rclee06

148419

Card Set

Renal Dose Adjustments

Description

Renal Quiz 2

Updated

2012-04-18T23:18:51Z

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