-
Serous
-benign
-borderline
-malignant
- Surface epithelial-stromal tumor
- Most common
- Lined with tall, columnar cells
- 20-45yrs
- Benign - cystic smooth
- Borderline - papillary projections, psamomma
- Malignant - multifocal, psamomma, invasion
-
Mucinous
-benign
-borderline
-malignant
- Surface epithelial-stromal tumor
- Middle adults
- KRAS
- Mucin filled cysts "sandy/gooey"
-
Endometrioid
-benign
-borderline
-malignant
- Surface epithelial-stromal tumor
- Mostly carcinomas
- Solid and cystic areas
- Tubular glands like endometrium
-
Clear Cell
-benign
-borderline
-malignant
- Surface epithelial-stromal tumor
- Rare
- Large epithelial cells with abundant clear cytoplasm
-
Benign transitional cell tumor - Brenner
- Surface epithelial-stromal tumor
- Rare adenofibromas
- Combo of cystic and solid areas
- Coffee bean nuclei
-
Granulosa-Theca Cell Tumor
- Sex cord-stromal tumor
- Mostly postmenopausal
- Coffee bean nuclei, solid sheet of cells
- Elevated inhibin
-
Fibroma
- Sex cord-stromal tumor
- Fibroblasts
- Unilateral, encapsulated, hard
- Hormonally active
-
Thecoma
- Sex cord-stromal tumor
- Plump spindle cells with lipid
- Unilateral, encapsulated, hard
-
Sertoli Cell/Leydig cell tumor
- Sex cord-stromal tumor
- Pts 10-30
- Leydig = big, pink
- Sertoli = dark, blue
- Masculinization effects (rarely estrogenic)
- Well-diff tubules
-
Other rare sex cord tumors
-Leydig cell/Hilus cell
-Pregnancy luteoma
-Gonadoblastoma
- -Leydig cells with reinke crystalloids, elevated 17-ketosteroids
- -Pg luteoma - virilization
- -Gonadoblastoma - abnl sexual dev
-
Teratoma
-Mature benign
-Monodermal (specialized)
-Immature
- Mature: reproductive years, paraneoplastic, dermoid cysts, hair, teeth...
- Monodermal: struma ovarii (thyroid tissue) or carcinoid (intestinal tissue)
- Immature: average age=18, necrosis, hemorrhage, hair and bone and immature neural elements
-
Dysgerminoma
- Germ cell tumor
- High HCG
- Sheets of large vesicular cells, fibrous cord, lympho-plasmacytic infiltrate, granulomas
- Malignant
- Responsive to chemo
-
Yolk sac tumor
- Endodermal sinus is most common
- High alpha-fetoprotein
- Schiller Duval bodies
- Young pts
-
Metastatic
- Most often from GI (colonic, appendiceal, gastric)
- Most often asked about - breast
-
Choriocarcinoma
- Germ cell tumor
- High HCG
- Placental origin with synciotrophs and cytotrophobolasts
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