-
High Risk using Androgen Deprivation Therapy (ADT)
- osteoporosis
- insulin resistance
- hypercholesterolemia
- obesity
- cardiovascular disease
- depression
- gynecomastia
- hot flashes
-
LHRH adverse effects
- hot flashes
- erectile dysfunction and impotence
- decreased libido and depression
- injection-site reactions
-
antiandrogen adverse effects
- gynecomastia
- hot flashes
- breast tenderness
- GI (diarrhea, constipation)
- Liver function abnormalities (LFT)
-
Flutamide black box warning
hepatic injury
-
Nilutamide black box warning
- interstitial pneumonitis - can lead to pulmonary fibrosis
- symptoms: cough, dyspena upon exertion, chest pain, fever
-
Docetaxel Toxicity
- Acute toxicity: hypersensitivity
- Delayed toxicity: Neurotoxicity/peripheral neuropathy, fluid retention, myleosuppression w/neutropenia
- *treat fluid retention w/dexamethasone
-
Estramustine adverse effects
- myelosuppression
- estradiol-related effects: thrombosis, gynecomastia, impotence, fluid retention
-
Localized Symptoms of Prostate Cancer
- Stage I-II
- confined to prostate
- asymptomatic
-
Locally Invasive Symptoms of Prostate Cancer
- Stage III
- spread just beyond prostate (semincal vesicles)
- Ureteral dysfuntion: frequency, hesitantcy, dribbling
- Blood in urine/specimen: hematuria
- impotence
-
Advanced Disease Symptoms of Prostate Cancer
- Stage IV
- spread to lumbar spine, liver, lungs, brain
- back pain
- cord compression
- lower-extremity edema
- anemia
- pathologic fractures
- weight loss
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