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Best drugs for treating CAD
nitrates (also, beta blockers and CCB may be used)
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What do nitrates do
have a direct action on vascular smooth muscle and cause it to relax
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� life for nitro SL
1-4 minutes
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What do CCB do?
Dilate coronary arteries and reduce the response of the cardiac conduction system to electrical impulses and treat dysrhythmias
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Long acting nitrates are
used to prevent or treat angina attacks before they occur (i.e. with exercise)
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Nitrates are also used to reduce the work of the heart in
MI, CHF, relief of GB, GI, urethral and bronchial smooth muscle pain
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Peripheral vasodilating agents are used to treat pain in the legs caused by
intermittent claudication, arteriosclerosis obliterans, raynauds, nocturnal leg cramps and vasospam by blood clots
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Adverse reactions to nitrates
flushing, postural hypotension, tachycardia, confusion, dizziness, fainiting, vertigo, burning in the mouth, vomiting
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Tartrazine
may cause allergic reaction with symptoms like asthma
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Tolerance with nitrates may occur and high doses may cause violent headaches
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What reduces action of nitro
cold or use of tobacco and sunlight
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PV agents is stronger if
used with antihypertensives and alcohol may cause hypotension
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If blurred vision or dry mouth occus
stop nitrates
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Antidysrhythmics can cause or worsen CHF or urinary retention
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Side effects of nitro
flushing, throbbing headache (<20 min), increased heart rate, dizziness and lightheadedness
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How is nitro dispensed
dark glass bottle; 3 month shelf life
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Take nitro in empty stomach
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Inhalant nitrates should be taken
lying down or sitting
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Do not rub ointment into the skin
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Check BP before giving dose
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Don�t eat a lot of foods that may stimulate the heart
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Drugs that interact with nitrates
alcohol, antihistamines, antidepressants
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Vasodilators are used to treat pain in the legs because of their effect on
peripheral arterial system
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Side effect of Periph vasodilating agent
severe hypotension
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