S2M3 histo

- arrested in diplotene stage of prophase of meiosis 1 by OMI

• -single layer of flattened follicular cells surrounding the primary oocyte (arrested in prophase of meiosis 1)
• -balbania body- mtch and RNA binding proteins
• - annulate lamella- similar to nuclear envelope

- unilaminar- single layer of cuboidal or columnar follicular cells

- mulitlaminar- granulosa cells (proliferation due to activin)

-stroma cells reorganize into theca folliculi

• - protein coat that seperates oocyte from follicular cells
• - ZP3 glycoprotein- sperm receptor and involved in acrosomal reaction

- stromal cells around multilaminar follicle

• - steroid producing cells
• - contain LH receptors on membrane
• - produce androstenedione
• - (andriostenodione enters granulosa cell and is converted to estrogen( source of estrogen at puberty)

• - accumulations of fluid known as liquor folliculi amoung granulosa cells
• - granulosa accumulation depends on FSH
• - FSH + estrogen => granulosa cells expressing LH receptors

• M- secreted by Sertoli cells
• F- secreted by granulosa cells

• M- secreted by Sertolli cells
• F- secreted by oocyte

• - secrete estrogen untill menopause
• - granulosa cells of atretic follicles

- single fluid filled antrum

- single layer of granulosa cells immediately surrounding the primary oocyte

- mound of granulosa cells that surrounds and anchors the oocyte to the peripheral granulosa cells

• - day 14, surge of E shuts off FSH and causes LH surge
• LH surges causes
• - 1oocyte completes meiosis 1 and newly formed 2oocyte enters meiosis 2 and stops in metaphase(roughly 3 hrs before ovulation)
• - stigma formation==> opening into peritoneal cavity
• - 2oocyte with CR are released into peritoneal cavity
• - 2oocyte swept into fallopian tube by fimbrae (degeneration within 24 hrs if not fertilized)

• - initiates puberty
• - maintains corpus luteum
• - responsible for ovulation and the changes in the oocyte during ovulation (M1 completion, oocyte release, etc)

• - 2 cells types (granulosa lutein (80% LIGHT) and theca lutein(20% DARK)
• - secretes mainly progesterone (endometrium support and LH inhibition)
• - also secretes estrogen(inhibits FSH)
• - LH supports for ~first 10 days
• - if fertlization occurs hCG will induce longer life

• - in ovarian medulla
• - secretes androgens (similar to leydig cells in males)
• - can give rise to masculinizing tumor

• - multilayer follicular cells stim by activin
• - surround oocyte just outside of ZP
• - convert androstenodione---->estrogen
• - secretes estrogen
• - when part of CL secretes mainly progesterone
• - forms interstitial glands

• - touch receptors
• - located in the stratum basale
• - abundantin skin where sensory perception is acute

• - pressure and vibration sensors
• - located in the hypodermis
• - myelinated nerve ending surrounded by a corpuscle (that resembles an onion
• - mechanically gated ion channel

• -fine touch, heat, cold, pain and itch sensors
• - terminate in the stratum granulosum
• - surround most hair follicle and sensitive to hair movement

• - touch recpetors
• - in dermal papillae
• - respond to slight deformation of the epidermis
• -common areas sensitive to tactile stimulation (lips, nipples and external genetalia
• - mechanically gated ion channel

• - stretch receptors (particularly sensitive to cutaneous stretching)
• - found in hypodermis
• - spindle shaped
• - mechanically gated ion channel

• - found all over the body in reticular layer of dermis
• - secrete sweat
• - SNS controlled myoepithelial cells at base and aid secretion
• - important in thermoregulation
• - simple coiled tubular glands that open into sweat pores
• - duct(stratified cuboidal) is always darker than the gland(columnar)

• - found in the arm pit, areola and anal region
• - secrete a viscous secretion and pheremones
• - ducts open into hair follicles
• - actually merocrine glands(secrete by exocytosis)
• - very wide lumen