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alternative splicing.txt
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Alternative splicing
process by which MULTIPLE mRNA molecules made from single pre-mRNA
Recognition of splice sites requires RNA BINDING PROTEINS
significant fraction (4%) of alternative splicing associates with RNA secondary structure formation.
RNA 2ndary structure definition
single-stranded RNA likely to take on secondary folds that can influences SPLICE-SITE selection
Role of RNA 2ndary structure
these structures may last long enough to INTERFERE with or MODIFY splice-site IDentification
1. interfere with splicesome assembly by concealing SPLICE sites or enhancing binding sites
2. Promote spliceosomal assembly by MASKING SILENCER binding sites
Ability of GC content to enhance formation of secondary structures
Higher GC content = Greater molecular stability
if pre-mRNA structures have higher GC sequences, they are stable and will promote alternative splicing
Author
rincrocci
ID
144044
Card Set
alternative splicing.txt
Description
alternative splicing
Updated
2012-03-26T23:49:25Z
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