GEN #18 Gene Therapy I unfinished

The manipulation of an individuals genomic information to produce a therapeutic outcome is _______

A liver disease that cause high ammonia levels and is abbreviated OTC is

ADA deficiency causes

Ways to treat acquired diseases are

Gene augmentation therapy refers to an acquired ______ function

Generally the introduction of_______will overcome a loss of gene defect

___________ removes a specific cell population from the body

Inserting a gene to code for a cellular toxin is an example of ________

Direct killing of diseased cells can be done by inserting a __________ or a ___________

Prodrug activation therapy requires viral _________ to be transfected into cells

ganciclovir is ___________ by the viral TK

_________ finish adding phosphate and ganciclovir blocks cell division.

ganciclovir monophosphate enters adjacent cells through ______ formed by ________

ganciclovir monophosphate is ________ in the adjacent cell and kills that cell as well

_________ substitutes a wild-type gene in place of a gene that has been altered due to chemical, viral, or physical injury

Correction of a Gene Mutation uses __________ to do replacement

Targeted Gene Editing disrupts a single gene using a _______ approach

zinc finger nuclease is an engineered fusion protein containing

Fokl needs to ______for activity using two ________ proteins

If DNA binding domain contains ________ covering ___ zinc finger domains, will provide unique specificity of binding.

2 most popular viral systems are