1. Transmission of Polio
    • Communicable (fecal-oral)
    • Respiratory Dz/GI Dz to PNS to CNS
  2. S/S of Polio
    • * Asymptomatic (95%)
    • * Minor illness (fever, malaise, sore throat) (5%)
    • * Nonparalytic/aseptic (swollen meninges)
    • * Paralytic/major illness (motor cortex) (1%)
    • * Skeletal not sensory to CNS
  3. Organism of Polio
    • Enterovirus
    • 3 serotypes
    • RNA, plus strand-same sequence between gene and mRNA
  4. Polio Paralysis
    • CD155 receptor virus binds, found on various cells, diff variations of CD155-->more likely for polio to recognize
    • Interfon receptor lack -->inteferon dec viral load, cells missing
    • Paracrine (on other cells); autocrine (self)
    • Cell issues with immune response and close cells
  5. Viral Replication
    • Some cells better than others secondary (immune cell activation) lymph tissue
    • Replicate in respiratory and GI tract (Reyer�s patches)
    • Capsid binds to CD155 inject whole RNA genome
    • Genome translates into one protein
    • Bring viral protease that cut off 5 prime caps of mRNA
    • Makes it sequence the only thing to translate
  6. Organization for polio
    March of Dimes-->FDR
  7. Vaccines for Polio
    • IPV (inactived)
    • OPV (sabin)
    • Live attenuated
    • Reversion issues
  8. Reversion issues of OPV
    • CVDPV (circulating vacc derived polio virus)
    • Mutates to dz causing form
    • VAP (vacc derived poliomyelitis)
  9. Poliomyelitis Causative Org
  10. Poliomyelitis Virulence Factors
    Attachment Mechanism (CD155)
  11. Poliomyelitis Modes of Transmission
    Fecal-oral, vehicle
  12. Poliomyelitis Treatment
    None, palliative, supportive
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