What are the 2 therapeutic uses for Clondine?
Pharmacological effects of Clonidine?
Bradycardia/ decrease CO
Minimal orthostatic hypertension
What are the main adverse effects of Clonidine?
- *Severe Rebound Hypertension
Others: constipation, impotence, gynecomastia, CNS effects
Is Clonidine ok to use in pregnancy?
If someone was wanting to stop taking Clonidine, what would you teach them?
Withdraw slowly over 2-4 days to prevent rebound hypertension
How would you teach someone to administer Clonidine?
Transdermal patch applied every 7 days applied to hairless upper arm or torso
What is the mechanism of action of Methyldopa?
Lowers BP by working within CNS
What are the pharmacological effects of Methyldopa?
Vasodilation (not cardio suppression)
Lowers BP in supine and standing subjects
Therapeutic use of Methyldopa?
Adverse effects of Methyldopa?
-Positive Coombs' test & hemolytic anemia
What are the 2 pharmacological effects for Resperine?
-Peripheral Effects (slows HR & reduces CO)
-CNS Effects (sedation)
Therapeutic uses of Resperine?
Hypertension & Psychotic state (not preferred)
Adverse Effects of Resperine?
- -Bradycardia, orthostatic hypotension, nasal congestion
- -GI involvement
What is Prazosin used for?
- -Relaxes bladder sphincter
Adverse effects of Prazosin?
- -No (very little) singular use for BP
- -1st dose phenomena
- -Nasal Congestion
What are the 3 uses of Dopamine?
-Shock (increases cardiac output and renal perfusion)
-Heart Failure (increases myocardial contractility)
-Acute renal failure (preserves renal function)
Adverse effects of Dopamine?
-Tachycardia, dyrhythmias, anginal pain
-Necrosis with extravasation
Drug interactions of Dopamine?
How must Dopamine be administered?
Must be diluted and given by IV
What are the therapeutic uses of Norepinephrine?
- Hypotensive emergency
- Cardiac Arrest
What is a side effect that epinephrine causes but norepinephrine does not?
What is the drug of choice for anaphylactic shock?
Therapeutic uses of epinephrine?
- -anaphylactic shock
- -delays absorption of local anesthetic
- -control superficial bleeding
- -elevate blood pressure
- -bronchial dilation (asthma)
- -overcome AV block
- -restore function in cardiac arrest
Adverse effects of epinephrine?
- -hypertensive crisis
- -angina pectoris
- -necrosis upon extravasation
Drug interactions with Epinephrine?
- General Anesthetics
- Alpha & Beta adrenergic blocking agents
Contraindications of Propanolol?
- Severe Allergy
- Cardiac, respiratory, psychiatric disorders
Drug interactions of Propanolol?
- Calcium channel blockers
Pharmacologic effect of Atropin?
Therapeutic uses of Atropine?
- -eye pressure disorder
Adverse effect of of Atropine?