Lidocaine (Xylocaine)

Antidysrhythmic

amide-type local anesthetic use to treat life threatening dysrhythmias.

Depresses depolarization and automaticity in the ventricles with little effect on atrial tissue. Therapeutic doses does not slow AV conduction or depress myocardial contractility.

• Onset: < 3min
• Peak: 5-7 min
• Duration: 10-20 min
• Half-life 1.5-2 hrs

V-Tach and V-Fib refractory to Amiodarone

• 2nd & 3rd degree heart block
• PVC's with Bradycardia

• CNS depression when doses exceed 300mg/hr ; which can lead to coma or death.
• Monitor for CNS toxicity
• Pts over 70 years old reduce dose by 50%

• Hypotension
• Nausea
• Bradycardia
• Vomiting
• Heart Blocks
• Seizures
• Cardiac & Respirtory Arrest
• Confusion
• Drowsiness
• Slurred speech

• V-tach: Loading dose of 1.0-1.5mg/kg followed by
• 0.5 – 0.75mg/kg every 5-10 min as needed

1mg/kg

3mg/kg

2-4mg/min after dysrhythmia is gone

IV/IO

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