Which is the correct term when pertaining to pituitary hormones? tropic or trophic
GHRH ______ release of GH while somatostatin _______ release of GH
Dopamine ____ release of prolactin
___ directly stimulates IGF-1 release, which binds IGF1 receptors and ____ receptors in serum.
GHR activation activates IRS/PI3K pathway which affects _______ transporters
Also activates MAPK which expresses genes including _____
IGF-1 binding receptors results in many pathways being activated, including ____ which has growth effects
Both adults and children with GH deficiency can be treated with ___ however children may also be treated with ____. Treatment in children should be before bone _____ close.
GH treatment in adults is indicated for GH deficiency associated with ______, _____ associated wasting, and ____ due to short bowel syndrome.
Idiopathic short stature in children is a height that is _____ SDs below normal
Serostim, Genotropin, Humatrope, Nutropin, Norditropin, and Saizen are what kind of GH products?
GH look alikes
what is mecasermin and what is its primary use?
used for treatment fo children with severe primary IGF-1 deficiency (gene defect)
GH in ____ side effects include edema, carpel tunnel, arthralgia.
GH in ____ side effects include impaired glucose tolerance, scoliosis, intracranial hypertension
IGF-1 side effects include insulin effects like ______ and ______, also intracranial hypertension, scoliosis
lipohypertrophy and hypoglycemia
What 3 pharmacological treatments can be used for GH excess?