Toxic Substances

Toxic Effects

Potency X Exposure
Toxic Effect

Any adverse response ina n orgnaism cuased by a chemical
Potency

The rate at which a chemcial causes an effect
Exposure

Contact with a chmical
Dose

The amount of chemicla required to produce the deleterious effect
LD₅₀

The dose required to cuase death in 50% of exposed animals
Acute Toxicity

Ability to cuase harm as a result of a one-time exposure to a substance
Chronic Toxicity

Ability to cause harm via a repeated low-dose exposure over a long period of time
Routes of Exposure
- Oral
- Dermal
- Respiratory
Synergism
- The interaction fo two or more substances that produces an impact greater than the sum of their independent effects
- 1+1=5
- Smoking + anything
- Hepatitis B/C and drinking
Other Factors Determining toxicity:
- Size
- Age
- Sex
- Genetic Variation
- Species
- Developmental Status
- Traditionally based on a 70kg male
Remediation
- Removie toxic from the environment (end of pipe stratgy)
- incineration
- filtration
- sterilizaiton
- chemcial treatment
Cancer/Children
- Cancer rates in children have been rising nearly 1% per year
- Children ahve less fat than adults- less of a toxic sink
- children have dramatically reduced detoxification and repair system, as compared to adults
- Chidlren have reduced contorl of waht goes into their systems

Author

Cartejer

142194

Card Set

Toxic Substances

Description

BOOM BOOM ROOM

Updated

2012-03-18T04:10:42Z

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