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Class
- Mineral
- Electrolyte
- Anti-arrhythmic
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Description
- Salt that dissociates into Magnesium Cation (MG2+) and the sulfate anion when administered.
- Essential for many biochemical reactions in the body
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Mechanism of Action
- Physiological Calcium channel blocker
- Blocks neuromuscular transmissions
- Smooth muscle relaxant causing broncho & vasodilation
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Onset of Action
- Onset: Immediate
- Peak: Varies
- Duration: 1hr
- Half-life: N/A
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Indications
- Cardiac- Torsade de Pointes
- Respiratory- Severe bronchospasm, Asthma
- OB: Pre-eclampsia, eclampsia
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Contraindications
- Shock
- Severe/Persistant HTN
- 3rd degree heart block
- dialysis pts
- Hypocalcemia
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Precautions
- Administer SLOWLY
- Cardiac monitoring and vital signs
- Check knee and bicep reflexes before admin.
- Caution with renal insufficiency
- Elevated Magnesium levels can occur
- Calcium Chloride reverses effects
- Cardiac Conduction abnormalities with digitalis
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Side Effects
- Flushing
- Respiratory depression
- Drowsiness
- Arrhythmias
- Hypotension
- Itching
- Rash
- Sweating
- Bradycardia
- decreased deep tendon reflexes
- hypothermia
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Adult Dose
- Cardiac- 1-2g diluted in 100ml D5W or NS over 5min as IV piggyback
- Respiratory- 2g over 2-5min
- OB- 4-6g slowly over 30min
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Route of Administration
IV/IO/IM
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How Supplied
Prefilled 1g or 2g vials
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