What percent of ATP depletion leads to changes in neurologic cortical signs (e.g., speech, behavior, memory)? (p.1)
- When ATP levels falls to around 55% or normal, we see difficulty with conduction.
- Noted by outward neurological vital sign changes.
- Some examples of “cortical” signs are speech, behavior, memory, judgment, and personality changes.
- Cortical signs = heralding signs
At what temperature will brain cell death occur because of ATP depletion? (p.3)
- 106 degrees Fahrenheit
- Hyperthermia --> 10% increase in metabolic demand for every 1 degree Celsius increase in temperature over normal
- At temp of 106 degrees Fahrenheit, brain rapidly advances to vegetation and brain death due to rapid ATP depletion
In terms of time frame, when does seizure activity become a medical emergency? (p.3)
Seizure activity ongoing more than 20-30 minutes = medical emergency due to rapid ATP depletion
Review changes in blood flow during seizure activity (increased or decreased). (p.2)
- Seizure activity = rapid depletory of ATP
- Patient who can will attempt to increase cerebral blood flow as much as 250-300% in an attempt to meet metabolic demands of seizure activity.