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The eyes develop from an extension of the ____ ____ in combination with the overlying ______ and the surface ______ in the head region.
- neural tube
- mesenchyme
- ectoderm
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Development of the eyes begin when the future diencephalic region of the neural tube forms lateral evaginations called___ ____.
optic vesicles
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The optic vesicles are attached to the neural tube by an ___ ___.
Optic stalk
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The optic vesicles project from the neural tube towards the surface ectoderm. The distal end of the optic vesicle, called the ___ ___, invaginates to form the ___ ____.
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The lens placode is a thickening of the __ ___ opposite to the optic cup.
surface ectoderm
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The lens placode invaginates to form the __ ___, which buds off from the surface ectoderm and moves into the lumen of the ___ ___ to become the ___ ____.
- lens pit
- optic cup
- lens vesicle
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An intervening layer of ____ seperates the lens vesicle from the optic cup.
mesenchyme
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Where does the primary vitreous body form?
in the lentiretinal space
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The cavity of the lens vesicle is overtaken by the growth of __ ___ __.
primary lens fibers
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Ventrally, the optic stalk forms the __ ___.
choriodal (retinal) fissure
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The hyaloid artery is a branch of the ___ ___ and supplies the developing ___ and ___. The hyaloid artery gains access to the interior of the optic cup via the ___ ____.
- opthalamic artery
- lens
- retina
- choroidal fissure
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The mature lens does not need a blood supply, therefore thedistal end of the ___ ___ will degenerate while the proximal portion remains the ___ ___ of the retina.
- hyaloid artery
- central artery
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The optic cup consists of two layers of neuroepthelium seperated by a cavity continuos with the ___ ___.
ventricular system
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The outer layers of the neuroepithelium will differentiate into the ___ ___ and the intervening cavity is called the___ ___.
- pigmented retina
- intraretinal space
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The inner layer of the neuroepithelium of the optic cup develops into the ___ ___.
neural retina
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The cells of the neural retina proliferate to become the outer and inner ____ ____.
neuroblastic layers
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The outer neuroblastic layer forms the ___ and ____.
rods and cones
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The cells of the inner neuroblastic layer form the ___ and ___ ___of the retina.
ganglion and supporting cells
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The ganglion extend their axons through the __ __ mostly targeting the ___ ___ ___.
- optic stalk
- lateral geniculate nucleus
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The optic nerve develops when the ____ ___ send axons into the optic stalk targeting the ___ ____ ___.
- ganglion cells
- lateratl geniculate nucleus
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The ___ ___ is eventually obliterated by the coming together of the neural and pigmented retinas.
intraretinal space
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A retinal detachment refers to the seperation of the ___ ___ from ___ ___.
- neural retina
- pigmented retina
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The mesenchyme surrounding the optic cup condenses, forming two separate layers. The inner layer forms a pigmented and vascular layer called the ____, which is continuous with the pia and arachnoid maters of the rest of the brain. The outer layer forms the ______, which is continuous with the dura mater.
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The choroid is continuous with??
The sclera is continuos with?
- The pia and subarachnoid mater
- The dura mater
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Mesenchyme surrounding the developing eye invades the space between the lens vesicle and the surface ectoderm. This mesenchyme splits into a ___ ____ layer (closer to the surface ectoderm) that is continuous with the ____, and a deep pupillary membrane (near the lens) that is
continuous with the _____.
- superficial stroma layers
- sclera
- choroid
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The cavity between the stroma layer and the pupillary membrane of the mesenchyme becomes the ___ ___. The posterior portion of the thick pupillary membrane (adjacent to the lens) breaks down, forming the ___ ___. Eventually, the thin remaining portion of the pupillary membrane breaks down, creating the ______.
- anterior chamber
- posterior chamber
- pupil
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The cornea has three layers: a superficial epithelium derived
from surface ectoderm, a __ __, and a deep mesothelial layer that lines the __ __. The invaginating cells that do not oppose the stromal layer
form the __, which lines the conjunctival sac.
- middle mesenchyme
- anterior chamber
- conjunctiva
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The upper and lower eyelids develop as folds of the surface ectoderm (with a core of mesenchyme). These folds grow toward each other and fuse, only to separate again before birth. The __ ____ form as invaginations of the ectoderm of the conjunctival sacs.
lacrimal glands
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The inner and outer layers of the optic cup that come to overly the lens anteriorly, together with the overlying choroidal mesenchyme, develop into the __ and __ ___ .
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The iris consists of three layers, an inner nonpigmented
layer continuous with the ___ ___, a pigmented middle layer continuous with the ___ ___, and an outer mesenchymal layer derived
mostly from neural crest cells.
- neural retina
- pigmented retina
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The pupillary muscles develop within the __ .
iris
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The ciliary processes, ciliary muscle, and suspensory ligaments all develop from the __ ___. The extraocular muscles (medial rectus, etc.) are derived from ___ ___, not pharyngeal arch musculature. Therefore, these muscles are innervated by ___ fibers, and not brachial efferent (BE) fibers.
- ciliary body
- occipital somites
- general somatic efferent (GSE)
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anophthalmia
absence of an eyeball
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congenital cataracts
the lens becomes opaque during embryonic development
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congenital glaucoma
increased intraocular tension
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persistent pupillary membrane
connective tissue strands across the pupil
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atresia of the pupil
persistence of the entire pupillary membrane
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cryptophthalmos
absence of eyelids, so that skin covers the eye
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synophthalmia
fusion of the eyes
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coloboma
This deficiency may extend to the inferior portion of the iris ___ ___ and may affect the ciliary body. Fissures in the eyelid __ __are uncommon, but most often occur in the upper lid.
failure of the choroid fissure to close, a cleft persists on the ventral side of the developing optic nerve and retina.
- (coloboma iridis)
- (palpebral coloboma)
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