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Smooth muscle
- Single nucleus
- No striations, hollow organs/blood vessels (gap junctions)
- Involuntary
- Slow/long contraction (do not contract at once)
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Cardiac muscle
- Single nucleus (per cell)
- Branched nucleus
- Striations
- Heart wall
- Intercalated disks
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Intercalated disks
Plasma membranes jam packed with gap junctions passing back and forth through the cell
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Skeletal Muscle
- Multinucleated
- Striated
- Voluntary
- Attached to skeleton
- Cells run entire length of muscle
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Skeletal Muscle Functions
- 1. Support body
- 2. Make bones move
- 3. Help maintain body temperature
- 4. Help cardiovascular/lymphatic vessel movement
- 5. Protect internal organs
- 6. Stabilize joints
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Vertebrates
Animals whose muscle is outside of vertebrae
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Skeletal Muscle Attachments
- Tendon
- Origin - lesser mobile bone (ex: end next to ball-and-socket joint)
- Insertion - more mobile bone (ex: closer to hinge (elbow))
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Skeletal Muscle Names
- 1. Size
- 2. Shape
- 3. Location
- 4. Fiber direction
- 5. Attachment
- 6. Number of attachments
- 7. Action
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Muscle Contraction
Pull insertion closer to origin
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Muscle movement
- Prime mover � main moving muscle
- Synergist � working together in the same movement
- Antagonist � opposite movement
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Basic skeletal muscle
- Whole muscle --> Muscle bundle (fascicle) --> Single muscle cell (fiber) --> myofibril --> myosin, actin, sarcomere, z-line
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Skeletal Muscle Cell Structure
- Sarcolemma: plasma membrane (plasmalemma)
- Sarcoplasm: cytoplasm
- Sarcoplasmic Reticulum: endoplasmic reticulum
- T-Tubule: stored calcium (made of sarcolemma)
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Neuromuscular Junction
- Glycogen for ATP
- Lots of mitochondria
- Sarcolemma
- Synaptic cleft (junction between 2 cells)
- Acetylcholine in vesicles
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Muscle Fiber Contraction
- Step 1:
- Nerve impulses arrive
- Acetylcholine (ACh) is released (neurotransmitter) by exocytosis
- Step 2:
- Ach in synaptic cleft
- Binds to receptors in sarcolemma
- Impulses spread along sarcolemma
- Travels down t-tubule
- Arrives in sarcoplasmic reticulum where calcium is stored
- Step 3:
- Calcium released from SR
- Binds with troponin
- Causes shift in tropomyosin
- Biding sites on actin exposed
- Myosin binds to actin
- Step 4:
- Myosin bends and pulls actin
- ATP energy used
- Calcium unbinds
- ATP binds/energy used
- Myosin detaches from actin
- Process repeats and muscle shortens
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Muscle Cramp
- Contracting but not relaxing
- Dehydrated
- Imbalanced ions
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Botox
- Made from botulism
- No muscle contraction
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Rigor Mortis
- No ATP is released for relaxation
- Rigor mortis goes away�.EVENTUALLY
- Lysosomes begin destroying proteins making everything detach
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Tetanus
- Found in dirt
- If puncture in a place of no oxygen, releases toxin
- Produces exotoxin
- Prevent muscle relaxation
- Makes us contract so much that we begin breaking bones
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Motor unit
Motor neuron and all muscle fiber it innervates (controls)
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Axon
- Muscle fiber ratio
- Axons controlling smaller amounts of fiber have more controlled movements
- Axons controlling more amounts of fiber have more strength in movement
- Eye muscles 1:23
- Leg Muscle 1:1000
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All-or-None Principle
Muscle fibers that the axon is connected to will all contract or none of them will contract
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Slow Twitch Muscle Fibers
- "Dark" meat - leg and thigh
- More blood vessels
- Myoglobin stores oxygen
- Aerobic (move to mitochondria and make lots of ATP)
- Breaks down ATP slowly and continuously
- Long-term exercising
- High endurance
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Fast Twitch Muscle Fibers
- "White" meat - breast and upper wing
- Short-term contraction
- Explosive
- Fatigues easily because it uses all ATP quickly
- Anaerobic (without oxygen)
- Less mitochondria
- Strength
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Why Stretch? Warm up/Cool down?
- Before:
- Increase heart rate for oxygen going to muscle
- Decrease risk of pulling muscle
- After:
- Increase range of motion
- Cool down:
- Need to keep blood flowing by decreasing intensity of exercise
- Extra blood flow to decrease lactic acid
- Need ATP
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