GEN #16 Therapeutic Monoclonal Antibodies unfinished

Monospecific antibodies are produced by cells that all originate from a single _________ cell

The only major mouse monoclonal antibody available for human administration is ______

OKT3 is an ____________ and therefore minimizes ___________

The 2 types of monoclonal antibodies are _______ which ends in _____ and ________ which ends in _______

Chimeric antibodies are composed of _________ sequence the rest human antibody sequence

In chimeric monoclonal antibodies the V-region remains as _______ , while the remaining protein is ________ antibody
sequence

Humanized monoclonal antibodies are composed of ______ mouse protein

In humanized monoclonal antibodies just the ______ is taken from the mouse

Proteins are expressed in eukaryotic cells due to _________
requirements

From the _______ sequences, one can identify the CDR limits because they are flanked by conserved ___ and _____ chain sequences

6 pairs of _________ are generated for PCR amplification of the ________

____________ ________ is used to sequentially introduce the CDRs into the human homolog

After _____ cycles of mutation, the ______ that is essentially human, with binding sites coded for by the _________

What agent is associated with VEGF and used to treat colorectal cancer

Two primary mechanisms for how antibodies are able to kill cells

Gemtuzumab is associated with what antigen & what is it used to treat

Antibody-dependent cellular cytotoxicity (ADCC) uses _______ to induce apoptosis in targeted
cells by the release of ________, ___________ and
___________

What agent is used to treat T-cell mycosis fungoides, and what antigen is it associated with

Complement-mediated cytotoxicity (CDC) uses complement to bind the _______ and then insert into the _________ to
form the ______________.

Complement-mediated cytotoxicity (CDC) results in disruption of the ___________ of the tumor cell.

What agent was initially approved for relapsed indolent lymphomas that increases sensitivity of tumor cells to the apoptotic effects of traditional chemotherapeutic agents

Rituximab binds to CD20 and activates a ____________ which induces ________ expression and expression of _________ antigen