EBM Exam 2

  1. Non ingeriority margin
    • not possible to determine exact equivalency
    • determined a priori
    • used to determine relative effect of test drug test drug to reference drug
    • smallest value that would be clinically significant
  2. if upper level of the CI crosses the NI margin
    non inferiority not shown
  3. null hypothesis in non-inferiority trials
    • you will see a difference
    • you will not see non-inferiority
  4. alternative hypothesis in non-inferiority trials
    you will not see a difference
  5. superiority vs non-inferiority trials reguarding P-values and sample size
    • use CI instead of P-value because you have to see the upper limit
    • requires larger sample size than superiority trial
Card Set
EBM Exam 2
Beyond basic trial design