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Class
Calcium Channel Blocker (class IV antiarrhythmic)
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Description
Calcium ion agonist. Causes relaxation of vascular smooth muscle and slow conduction through AV nodr
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Mechanism of Action
Slows conduction through AV node, causes vasodilation, decreases rate of vascular response, decreases myocardial oxygen demand.
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Onset of Action
- Onset: 3 min
- Peak: 7 min
- Duration: 1-3 hrs
- Half-life 2 hrs
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Indications
Narrow complex tachycardia, SVT refractory to Adenosine, control ventricular rate for A-Fib and A-Flutter
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Contraindications
Severe hypotension, CHF, caridogenic shock, wide complex tachycardia, conduction system disturbance, Wolff-Parkinson-white syndrome, IV beta blockers
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Precautions
Must monitor BP! Keep refrigerated (30 day shelf life at room temp)
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Side Effects
- nausea
- vomiting
- hypotension
- dizziness
- headache
- bradycardia
- heart block
- asystole
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Adult dose
0.25mg/kg IV bolus over 2 min. After 15 min 0.35mg/kg if converted maintenance dose of 5-15mg/hr
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Max Dose
One dose Max 25mg
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Route of Administration
IV/IO
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How Supplied
Prefilled syringes, vials
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