Autonomic Drugs- Cholinomimetic

sympathomimetic drug that facilitates the release of catecholamines from adrenergic nerve endings

inhibit uptake of Ach into transmitter vesicles of cholinergic nerve

inhibit the transport of choline into the nerve terminal

Bacterial toxin that enzymatically disables release of acetylcholine from cholinergic nerve endings

Drug that impairs reuptake of catecholamine transmitters (NE, dopamine) by adrenergic nerve endings

renal vasodilation, CNS

neurotransmitter in CNS

drug that inhibits uptake of dopamine and NE into transmitter vesicles of adrenergic nerves

inhibits release of dopamine and NE from adrenergic nerve terminal

• Clinical Use: Postoperative and neurogenic ileus and urinary retention
• resistant to AChE

Glaucoma, pupillary contraction, and relief of intraocular pressure

• Potent stimulator of sweat, tears, saliva
• resistant to AChE

Use: Challenge test for diagnosis of asthma

postoperative and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular junction blockade (postoperative)

myasthenia gravis (long acting)

diagnosis of myasthenia gravis

Glaucoma (crosses blood-brain barrier --> CNS) and atropine overdose

Glaucoma

Alzheimer's disease

• organophosphates: parathion that irreversibly inhibit AchE. "-thion", malathion, Sarin & tabun (nerve gases; terrorist threat)
• Diarrhea
• Urination
• Miosis
• Bronchospasm
• Bradycardia
• Excitation of skeletal muscle and CNS
• Lacrimation
• Sweating
• Salivation
• Antidote- atropine + pralidoxime(regenerates active AchE)