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Antibodies are _ shaped
Y
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The two parts of the antibody are __ and __
Fab and Fc
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Antibody chains are held together by __ bonds
Disulfide
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Antibodies have __ and __ regions
Variable, constant
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Antibodies are made of __ and __ chains
Light, heavy
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The Fab region is the __ part of the Y
2 short branches
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the Fc region is the __ part of the Y
base
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the antigen-binding site is on the __ region of antibodies
Fab
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What are the 6 ways antibodies fight bacterial and viral infections
Neutralize, inferefere, agglutinate, opsonize, activate complement, tag
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What are the five classes of antibodies (based on Fc part): Ig_
M, G, A, D, E
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Ig_ is the first response
M
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IgM Fc parts join together to form a __
Pentanamer
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Ig_ is a main serum that�s the longest lived
G
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Ig_ can be transported across the placenta from mom to baby
G
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Ig_ is mainly secreted by mucuous membrane
A
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IgA is the most abundant class formed and joins together to form __
Dimers
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Ig_ is found on memory B cells
D
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IgD has a very __ half life
Short
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Ig_ is responsible for allergic responses
E
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How do antibodies differentiate
Antibody-producing cells undergo class switching
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__ is the cytokine signal that stimulates class switching
interleukins
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the first immune response produces Ig_ and some Ig_
M, G
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The second immune response produces mostly Ig_
G
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Antibody chains are put together by __
Combining parts
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A heavy chain is a combination of the _, _, and _ regions
VDJ
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A light chain is combination of the _ and _ regions
VJ
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B cells produce __, or B cell receptors
Surface bound Ab
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If an activated helper T cell recognizes an epitope on the B cell, it will bind to the B cell and create a __
MHC II/Antigen complex
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After activation, a B cell can become a __ that secretes antibodies
Plasma cell
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The helper t cell secretes cytokines that cause B cell to __
Makes clones of itself
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B cells that can bind Ag in the bone marrow of a fetus undergo __
Apoptosis
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If a B cell presents an epitope but no helper T cells can bind to activate it, the B cells becomes __
energic
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