1. physical barriers of innate immunity
    • skin
    • mucus membranes/secretion
    • directly expel organisms
    • lower temp of extremeties
  2. biochemical barrier to trap microorganisms
    tears, saliva, mucus, earwax, sebaceous glands, perspiration, acidic skin
  3. chemicals in biochemical barriers
    • lysozomes(muramidase)
    • lactic acid
    • antifungal/bacterial fatty acids
    • cathecidins
    • defensins
  4. organisms can be expelled via
    • coughing
    • sneezing
    • vomiting
    • peeing
  5. cathecidins are stored by
    • neutrophils
    • epithelial cells
    • mast cells
  6. cathecidin structure
    • linear alpha helix
    • amphipathic
  7. cathecidin and MOA
    activated by neutrophil protease elastase and inserts into the cholesterol free member of bacteria disrupting and killing it
  8. defensins are stored by
    • epithelial cells
    • mast cells
    • neutrophils
    • monocytes
  9. defensin MOA
    like cathelicidins but can also activate innate and immune system
  10. collectins are made of
    glycoproteins from the lung
  11. MLB is an example of what and MOA
    • collectin
    • recognizes carbohydrate patterns on pathogenic
    • miroorganisms
  12. MLB is part of which pathway
  13. the different types of colelctins (A-D) have different characteristics that help them
    binding to different types of pathogens
  14. cellular products released during inflammatory response
    • mast cells
    • monocytes/macrophages
    • cellular receptors
    • phagocytes
    • eosinophils
    • NK cells
    • vascular response
    • plasma protein system
  15. cytokines/chemokines
    • pro/anti-inflammatory depending on response
    • secrete soluble factors that contribute to regulation of innate or acquired resistance by affecting other neighboring cells
    • signaling cells
  16. visible changes during inflammation
    • redness
    • heat
    • swelling
    • pain
  17. four chemical mediators and function
    • histamine
    • bradykinins
    • leudotreins
    • prostaglandins
    • function to stimulate endothelial cells that line capillaries and venules to retract
    • provide spaces for cells and plasma to enter tissure
  18. chemical mediator cells are released
    close to damaged area to increase blood flow to area and lets WBCs into area
  19. WBC, plasma proteins, biochemical mediators all act together to
    • prevent spread to healthy tissure
    • blood clot
    • fluids to dilute bacteria toxins/cell debris
    • attack bacteria
    • lymphatic drainage
    • healing/repair
  20. name the complement pathways
    • alternative
    • lectin
    • classic
  21. all complement cascades lead to
    MAC which then drill holes in the bacteria cell wall and kill it
  22. how is classic pathway initiated
    activated by antigen/antibody binding
  23. how is the lectin pathway initiated
    bacterial carbs, doesn't rely on Ab
  24. how is the alternative pathway initiated
    gram - bacteria and fungal cell wall polysaccharides
  25. C3a and C5a
    • anaphylatoxins
    • chemotaxic
    • induce mast cell degranulation
    • release histamince --> vasodilation and permeability
  26. C3b
    • opsonin
    • adheres to surface of pathogen
    • tag microorganisms for destruction by cells of the inflammatory system
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