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Clinical Trials in Neurology

  1. The study which showed that ASA was not inferior to Heparinin the secondary prevention of stroke in the setting of atrial fibrillation (acute)
    • HAEST - Heparin in Acute Embolic Stroke Trial
    • 2000

    RCT of 449 pts with AF and acute ischemic stroke comparing Dalteparin 100 IU/kg SC BID vs. ASA 160 mg QDAY

    • No difference in recurrent stroke after 14 days
    • or death at 3m
  2. The study which showed ASA was not inferior to Warfarin in the prevention of stroke
    • WARSS -
    • NEJM 2001

    2206 patients with noncardioembolic ischemic stroke randomized to Warfarin vs. ASA 325mg

    No difference in death or recurrent stroke after 2 yrs
  3. The study which showed that showed ASA was as good as and associated with a lower risk of bleeding than Warfarin in the treatment of intracranial stenogis.
    • WASID
    • NEJM 2005

    RCT of 569 patients with intracranial stenosis by angio or MRA randomized to Warfarin vs. ASA 1300mg/

    No difference + more bleeding in warfarin group
  4. The study which demonstrated that IM Midazolam was not inferior to IV Lorazepam in the acute treatment of status epilepticus
    • RAMPART
    • 2012
  5. Demonstrated a reduction in stroke risk from 2 to 1% in asymptomatic patients with >60% stenosis who underwent surgery
    ACAS - Asymptomatic Carotid Atherosclerosis Study
  6. Demonstrated the benefit of CEA over medical management in symptomatic patients with >70% stenosis with some benefit in patients with a 50 - 70% stenosis.
    NASCET - North American Symptomatic Carotid Endarterectomy Trial
  7. The study which established TPA as the standard of care
    NINDS
  8. The study which addressed the importance of blood pressure control in ICH
    INTERACT
Author
jollyvulcan
ID
137152
Card Set
Clinical Trials in Neurology
Description
A list of clinical trials in neurology and their impact on the field / practice
Updated

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