Meeting 2

• has 2 functions:
• 1) to act as a barrier
• 2) but things have to pass through/be transported through as well...this is what proteins are good for

• polypeptides of interest aren’t hydrophobic in any
• way but attach to the membrane using lipid anchors; anchors don’t span whole membrane; the peptides are functional only on ONE side of membrane

not covalently bonded to membrane; located at and are functional at the membrane; attached via weak interactions w/ head groups

• proteins that span the whole membrane and bridge between the 2 sides; essential for bridging exoplasmic & cytoplasmic
• -have both hydrophobic (for internal) and hydrophilic residues (to interact w/ head groups)

• aliphatic (cyclic) ones are extremely hydrophobic (3 out of the 8); these are the ones that can interact with fatty acids (especially cholesterol)
• -basically all those CH₃'s are good for fatty acid interactions

micelle's have no internal acques compartment; liposomes do