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Name for aspects of RBC evaluation
- -size
- -color
- -shape
- -inclusion bodies
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What is the size of a normal RBC?
- -6-8 microns
- -about the size of small lymphocyte
- -MCV 80-99 fl
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What is the shape of a normal RBC?
- -round and bi-concave disc
- -high surface-to-volume ratio (pliable,flexible, deformable) (capable of unusual changes in shape that are necessary to pass thru microcirculation)
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What is the color of a normal RBC?
- pink to reddish-orange (in wright stain) depends on amount of Hgb
- -normal size of cental pallor is 2-3 um in diameter
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The inclusion bodies lacks what?
nucleus and organelles, still able to function and survive for approx. 120 days
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this is any variation in size due to deficiency in the raw material and is associated w/ increased RDW
Anisocytosis
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What is the range for a normal RDW?
11.5-14.5%
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Anosocytosis is seen where?
- -most forms of anemia
- -leukemias
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 Name the cell
Anisocytosis
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What are the characteristics of a microcyte?
- *<6 microns
- *MCV is <80 fl
- *seen in: iron deficiency, Thalassemia, Lead poisoning, Sideroblastic Anemia
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Name this cell
microcytes
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Macrocytes are seen in what?
liver disease, post-splenectomy; megaloblastic process, hypothyroidism; chemotherapy & newborns
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This cell is >8 microns and MCV is >99 fl
macrocytes
-
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this cell has a decreased Hgb, increased central pallor, MCHC is <32%
Hypochromasia
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name some characteristics of Hyperchromasia
- -RBC's decreased surface-to-volume ratio
- -decreased to absent central pallor
- -increased volumes of hemoglobin
- -MCHC is >36, usually spherical not biconcave
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this refers to the entire red cell morphology in the scanned area if a peripheral smeal, and grade 1+ to 4+
poikilocytosis
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Name the grading scale for RBCs Morphology
- normal...5%
- slight...5-10%
- 1+..10-25%
- 2+...25-50%
- 3+...50-75%
- 4+...>75%
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this cell has no central pallor, its reduced surface-volume ratio, irreversible, due to abnormality of the cell membrane(Defect or loss of cell membrane)
spherocytes
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spherocytes are seen in what?
- -hereditary spherocytosis
- -immune Hemolytic anemia
- -post-transfusion
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Echinocytes is also called what?
crenated or burr cells
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this cell is 10-30 even evenly spicules distrubuted, and may artifact in origin due to specimen contamination, sharp tips.
echinocytes
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this cell occurs in small numbers, unevenly spaced spicules
true burr or echinocytes
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Echinocytes are associated with what?
- -uremia(waste in blood from kidney)
- -heart disease
- -dehydration
- -untreated hypothyroidism(slow metabolism)
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Acanthocytes have what range of irregularly spaced spicules
3-12, spicules vary in lenth and are blunt rather pointed
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