CV-Vasodilators

  1. Nitrates
    • Nitroglycerin, dilates veins & coronaries=orthostasis
    • Indications: Angina
  2. Hydralazine
    • Liberate NO from endothelium, PO
    • No venodilation=no ortho
    • Indications: HTN
    • SE: Reflex tachy, Fluid retention, Immunological SE(Lupus)
  3. Nitroprusside
    • Active metabolite=NO
    • Dilates both arteriole and venules, Decrease O2 demands
    • Indications: hypertensive emergency, for surgery
    • SE:arterial hypoxemia with COPD, Rebound HTN, cyanide
  4. Minoxidil
    • Opening K+ channels, Arteriolar vasodilations, renin stimulator
    • Indications: Severe HTN (last, never alone), Hair growth
    • SE: Incerase O2 demands
  5. Fenoldopam
    • D1 agonist, a2 agonist, dilate peripheral ateries and natriuresis
    • Indication: Hypertensive emergency
    • SE: IOP, Reflex tachy, HeadA (q15min monitor)
  6. Nesiritide
    • BNP=stimulate vasodilation and natriuresis, decrease preload
    • Suppress RAAS, CNS sympathetic outflow
    • Indications: IV for acute CHF with dyspnea at rest
  7. $Nifedipine
    • Procardia
    • DHP, Increase in CO
    • Indications: Angina, HTN
    • SE: Reflex tachy, Peripheral edema, Gingival hyperplsia
  8. $Amlodipine
    • Norvasc, Amvaz
    • DHP, Increase in CO
    • Indications: Angina, HTN
    • SE: Reflex tachy, Peripheral edema, Gingival hyperplsia
  9. Nimodipine
    • DHP, Increase in CO
    • Indications: Angina, HTN, *Subarachnoid hemorrhage(PO)
    • SE: Reflex tachy, Peripheral edema, Gingival hyperplsia
  10. Clevidipine
    • DHP, Increase in CO, *Only IV CCB
    • Indications: Angina, HTN
    • SE: Reflex tachy, Peripheral edema, Gingival hyperplsia
  11. $Verapamil
    • Calan, Isoptin, Covera
    • Negative Ino, Chronotorpy, Some vasodilation
    • Indications: Angina, HTN, Supraventricular tachycardias
    • SE: Cardiodepression, LV fail, AV block, Constipation, Peri.Ede
  12. $Diltiazem
    • Cardizem
    • Negative Ino, Chronotorpy, Some vasodilation
    • Indications: Angina, HTN, Supraventricular tachycardias
    • SE: Cardiodepression, LV fail, AV block, Constipation, Peri.Ede
  13. CCB Strength
    • Systemic: DHP>Verapail>Diltiazem
    • Coronary: DHP>Diltiazem>Verapamil
    • -ino,chorno: Verapamil>Diltiazem>DHP
Author
fallcloud13
ID
136962
Card Set
CV-Vasodilators
Description
CV_Vasodilators
Updated