1. True or False

    The pharmaceutical industry produces pure cocaine semi-synthetically.
  2. What is the molecular weight of cocaine?
  3. Name 3 morphological characteristics of the coca plant.
    • 1. the underside of the leaves has 2 line parallel to the midrib.
    • 2. the leaves are usually deciduous after the current season's growth
    • 3. the plant grows as a small to medium bush usually planted in row in large, hillside plantations.
    • 4. the genus Erythroxylum is the only natural source of the alkaloid cocaine
  4. True or False

    Most of the alkaloids found in the coca leaves are in the form of esters.
  5. Who introduced cocaine to Europe?
    A French chemist named Angelo Mariani
  6. What is the botanical name for the coca plant that is most commonly used for pharmaceutical and illicit production?
    Erythroxylum Coca Lamarck
  7. What are the 3 most important alkaloids forund in the coca leaves for pharmaceutical use?
    • 1. l-cocaine
    • 2. cinnamoylcocaine
    • 3. truxillines
  8. In pharmaceutical production of cocaine, the most important alkaloids are converted to one specific alkaloid, and then it is converted to cocaine. Name this alkaloid.
  9. What is coca paste, and what is another name for it?
    The 1st extraction from the leaves

  10. In the process of making cocaine what does the addition of potassium permanganate do?
    • it oxidizes the non-cocaine alkaloids.
    • the cis- and trans- cinnamoylococaines
  11. How many chiral centers does the cocaine moleclue have?
  12. Name the 3 diastereomers of cocaine.
    • pseudococaine
    • allococaine
    • allopseudococaine
  13. True or False

    Gas Chromotography is an ineffective way to separate the distereomers of cocaine.
  14. What is the most abundant alkaloids in the coca plant?
  15. Cocaine is a schedule ________ controlled substance.
  16. True or False

    Decocainizied leaves are controlled.

    They are not controlled because they do not contain cocaine or ecgonine.
  17. Cocaine HCL is _________ in water, while cocaine (base) is __________ in water.

  18. How can cocaine HCL be intoduced into the body?
    sniffing or snorting

    dissolving in water and injected intravenously with a syringe
  19. True or False

    The diastereomers of cocaine can be idntified by infrared spectroscopy.
  20. Why is cocaine used in the base form?
    so the melting point can be lowered and it can be smoked
  21. The precence of which alkaloids in a cocaine sample indicate that it is from a natural source?
    the cis- and trans- cinnamoylcocaine

    or cis- and trans- isomer
  22. Name 2 compunds that can be identified in human biological fluids of cocaine users.

  23. Explain how cocaine HCL is converted to "crack" cocaine.
    • 1. Cocaine HCL is dissolved in water & sodium bicarbonate - this makes the pH slightly basic
    • 2. Solution is heated to near boiling / cold water is then added to rapidly cool the solution
    • 3. After cooling the cocaine solidifies & falls to the bottom of the container.
  24. Explaine the process of "free basing".
    Which celebrity is associated with this method?
    • 1. Cocaine HCL is dissolved in water and ammonium hydroxide is added
    • 2. Cocainae "free base" is extracted into diethyl ether
    • 3. Ether is evaporated to dryness, the power that remains is cocaine (base)

    Richard Pryor
  25. True or False

    Only the levo-(l-) isomer of cocaine is controlled.

    any isomer of cocaine is controlled
  26. True or False

    Anhydroecgonine methyl ester is a natural ester in cocaine as well as an artifact of the GC.
  27. What is the significance of the law concerning the control of cocaine being changed in 1984?
    before 1984 only the levo isomer of cocaine was controlled

    after 1984 any isomer of cocaine is controlled
  28. Why is it important for a forensic scientist to determine if a cocaine sample is in the salt or base form?
    Federal sentencing guidelines allow for more serious penalties for cocaine "base"
Card Set
Drug Analysis