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When giving a medication for the first time, the health care person should assess what type of response
Hypersensitivity in patients with history of know allergies
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Name a example, trade name, and classification of a drug from a plant source
- Poppy Plant
- Morphine, Codeine
- Analgesic
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Name a example, trade name, and classification from the mineral drug source
- Zinc
- Zinc Oxide Ointment
- Sunscreen
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Name a example, trade name, and classification of a drug from a animal source
- Pancreas of a hog
- Insulin
- Antidiabetic hormone
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Name a example, trade name, and classification from a synthetic source
- meperidine
- demerol
- analgesic
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Name a example, trade name, and classification of a drug from a DNA source
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Has alllowed for the production of biological active substances that are in the body and can be used to treat certain diseases
Recombinant DNA
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Refers to the alteration of genes done in a lab setting
genetic engineering
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Used to slow the progession of HIV. Not a cure
Zidovudine/Retrovir
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Used to treat malignancies and management of AIDS related Kaposi sarcome
Interferon/Roferon A
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Used to slow progression of demetia in Alzehimer's patients. Removed from market because of toxicity
Tacrine/Cognex
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Name of two drugs that treat more than one disease at a time. This drug treats blood pressure and cholestrol
Caduet (combines Norvasc and Lipitor)
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Name the 4 drug processes
- Absorption
- Distribution
- Metabolism
- Execretion
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Passage of substance through a membrane into the bloodstream
Absorption
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Moving from the bloodstream into the tissues and fluids of the body
Distribution
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Physical and chemical alterations that a substance undergoes in the body
metabolism
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Eliminating waste products of drug metabolism from the body
Execretion
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Variables that affect the speed and efficiency of drugs being processed by the body
- Age
- Weight
- Gender
- Psychological State
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The action of two drugs working together in which one helps the other simultaneously for an effect that neither could produce alone
Synergism
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the action of two drugs in which one prolongs or multiplies the effect of the other
Potentiation
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The opposing action of two drugs in which one decreases or cancels out the effect of the other
Antagonism
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The amount of drug given for a particular therapeutic or desired effect
Dosage
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Initial high dose used to quickly elevate the level of the drug in the blood
loading dose
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Dose required to keep the drug blood level at a steady state in order to maintain the desired effect
Maintenance dose
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Amount of a drug that will produce harmful side effects or symptoms of poisoning
Toxic dose
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Dose that causes death
Lethal dose
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Dose that is customarily given adjusted according to variations from the norm
Therapeutic dose
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Name the 2 most common routes of adminstration
Enteral/ GI Tract
Parenteral
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The doctor's choice of a particulat route of administration of a drug may depend on
- desired effects
- absorption qualities
- drug supply
-
Immune response (allergy) to a drug may be of varying degrees
Hypersensitivity
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Severe, possible fatal, allergic response
Anaphylactic reaction
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Refers to the type of prepatation in which the drug is supplied
Drug form
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Refers to any route not involving the GI tract, including injection, topical and inhalation routes
Parenteral
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Injectable drug form. Drug is suspended and shaken, then dissolved in a sterile vehicle
Liquid
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Injectable drug form. Dry particles of drugs. the powder itself cannot be injected, it must be muxed with a diluting solution
Powder
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Term used for drugs that are powder that must be mixed with a solution before administering
Reconstitution
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A small volume of drug injected into a peripheral saline lock, attached to a vein.
Where it is manually pushed through
IV Push
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A large volume of fluids, often with drugs added, that infuses continually into a vein.
Slow push through
IV infusion/IV drip
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A drug diluted in moderate volume, usually using 2 bags, of fluid for intermittent infusion at specified intervals.
IV Piggyback
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Injected into the fatty layer of tissue below the skin by positioning the needle and syringe at a 45-degree angle
Subcutaneous
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Injected just beneath the skin, by positioning the needle bevel up and a 15 degree angle
Intradermal
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Injected into a catheter in the epidural space of the spinal canal
Epidural
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Name the less common parenteral routes
- Intraosseous-- Marrow of long bones
- Intraventricular-- heart ventricle
- Intraspinal-- Subarachnoid/CSF surrounding spinal cord
- Intracapsular-- capsule of a joint
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The second route for fast acting
inhalation
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Substances low in lipid solubility are absorbed best when given by other means than
GI Tract
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Severe hypersensitivity response could require CPR, may be fatal
Anaphylactic
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Immune response to a drug that may be of varying degrees
Hypersensitivity
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Opposite effect from drug that was expected
Paradoxical
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Unique, unusual response to a drug
Idiosyncrasy
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Effect from maternal drug administration that causes the development of physical defects in a fetus
Teratogenic
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Dermal patches are used to treat
- Angina
- Pain
- Motion Sickness
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Most common classification of drug given rectally
- Sedatives
- Anti Pyretics
- Antiemetics
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Type of preparation in which the drug is supplied
Drug form
-
-
Minerals used to prepare drugs
Iron, sulfur, potassium, silver and gold
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Cellular changes or drug actions that are followed by physiological changes
Effects of drugs
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Sedative and barbiturates are given in combination, resulting in depression
undesirable syngerism
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In the liver, a drug is broken down and altered to more soluble by proguts so it is more easily execreted by kidneys
Biotransformation
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How are drug effects generally categorized
- Systemic--whole body
- Local--certain area
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An affinity or attraction of a drug to a specific organ or cell
Selective distribution
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Drugs slightly acidic are absorbed well with
stomach mucosa
-
Drugs of an alkaline pH are absorbed better through the alkaline enviroment of
small intestine
-
Drug effects that reach widespread areas of the body are known as
systemic
-
Route of administeration that allows for slower consistent drug administration over time
Transdermal
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Any chemical substance ingested or applied on the body for the purpose of affecting body function is called
a drug
-
Historically, these were the primary source of drugs
Plants
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Medications contradicted for lactating mothers pass through this into breast milk
cell membrane
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Drug compounds are produced from artificial rather than natural substances
Synthetic
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Used in patients participating in a blind study
placebo
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If a patients circulation and renal function is inadequate, what effect does it have
Dangerously low blood pressure
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Sweet, flavored liquid drug form
Syrup
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Liquid drug that contains oils and fats in water
Emulsion
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Local soothing effect on throat or mouth
Lozenge
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Disk of compressed drug
Tablet
-
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Liquid drug that forms with alcohol base
Elixir
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Treatment for anaphalactic reaction
- CPR,
- Epinephrine
- Corticosteroid
- Antihistamine
-
The number that represents the diameter of the needle
Ranges from 18-27
Gauge
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A glass container sealed at top by rubber stopper
vial
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Delivers drug over a extended period of time
Sustain- released
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Tablet with special coating that resists disintegration by gastric juices because outside layer is
enteric-coated
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Drug doses are calculated according to
a patient's weight
-
A cardiac drug that must be given cautiously because it can cause toxicity
Digoxin
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What can be used to make a drug treatment for growth disorders
The pituitary gland from a cow
-
Increased effect of a drug demostrated when repeated doses accumulate in the body that can buil to a dangerous or toxic level
Tolerance
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Dibucaine ointment applied rectally which reduces hemorrhoidal pain
Describes a local effect of a drug
-
Doses that causes death
Lethal
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Amount of drug that will produce harmful side effects or symptoms of poisoning
Toxic
-
-
Name the Parenteral Routes
- Sublingual
- Injection
- Topical
- Inhalation
-
Drug contained within a gelatin-type container
Capsule
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liquid drug form in which the drug is totally and evely dissloved,
Appearance is clear, tather than cloudy or settled
Solution
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Drug suspended in a substance, such as cocoa butter, that melts at body temperture
Suppository
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Drug suspended in solution to be administered as an enema
Enema solution
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A semisolid preparation containg a drug, for external application
Cream or ointment
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A liquid preparation applied externally for treatment of skin disorders. Should be patted, not rubbed on skin
Lotion
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Preparation for external use that is rubbed on the skin as a couterirritant, to mask pain in the skin or muscles
Liniment
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Skin patch containing drug molecules that can be absorbed through the skin at varying rates to promote a consistent blood level
Dermal patch
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Drugs in sterile liquids to be applied by drops
Ear, eye, nose drops
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Used for ophthalmic use only
eye ointment
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The 3 most common disposable syringes
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