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What are the major functions of the urinary system?
- Regulation of volume,compositon, and pH
- Remove metabolic waste by making urine
- Rate of RBC production by producing Erythropoietin Regulate blood pressure by producing renin(enzyme-hormone)
- Regulate calcium ion absorptionby activating Vitiman D
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What makes up the urinary system?
- pair of kidneys
- pair of ureters
- urinary bladder
- urethra
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Located on either side of the vertebral column, high in the posterior wall of the abdominal cavity, between the 12th thoracic and 3rd lumbar vertebrae, retroperitoneal
kidneys
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Which kidney is higher and why?
Left (1.5-2cm) because right kidney is displaced by the liver
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Space behind parietal peritoneum
Retroperitoneal
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3 Tisssue layers that cover kidneys
- Renal capsule
- adipose capsule
- renal fascia
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What is the innermost fibrous tissue layer that covers the kidney?
renal capsule
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What is the middle tissue layer that covers the kidney?
adipose capsule
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What is the outermost tissue layer that covers the kidney and serves to anchor the kidney to surrounding tissues?
renal fascia
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12 cm long, 6cm wide, 3 cm thick, about 5 oz. in weight, reddish brown bean shaped organ
kidney
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Enterance to the renal sinus, point where ureter leaves kidney, and blood vessels, lymph vessels and nerves communicate with kidney
Hilum
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Indentation in the medial border
Hilum
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What will be found in the renal sinus?
- renal vessels
- renal pelvis
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Superior end of ureter, recieving area for urine
Renal pelvis
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Funnel-shaped sac
Renal pelvis
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What are the 2 kidney regions?
- Renal cortex
- Renal medulla
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Reddish outer region of kidney, contacts the renal capsule, appears granule due to arrangements of tiny tubules associated with nephrons
Renal cortex
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Continuations of the renal cortex that are separated by renal pyramids
renal columns
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Kidney's inner region composed of 5-18 conical tissue masses called renal pyramids
renal medulla
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The _____ of the renal pyramid is directed toward the renal cortex
base
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The _____ of the renal pyramid projects into the renal sinus
apex
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Apexes form the ________ of the pyramids
renal papillae
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Renal papillae project into _______
Minor calyx
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Monor calyx converge and form _____
Major calyx
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Major calyx merge to form the _______, the expanded portion of the ureter
renal pelvis
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Formed in the kidneys to remove metabolic waste from the blood
Urine
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Hormone produced in the kidney to stimulate RBC production
Erythropoietin
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Proteolytic enzyme-hormone that is produced in kidney and stimulates formation of vascoconstrictor Angiotensin
Renin(helps regulate BP)
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How does the kidney help regulate absorption of calcium ions?
activates vitamin D
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Which artery supplies the kidney with blood?
renal artery
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Where does the renal artery arise from?
abdominal aorta
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Where does the renal artery enter the kidney?
hilum
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Large diameters, conveys blood to the glomerulus of a nephron
afferent arterioles
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network of blood capillaries, site of filtration, only found in the renal cortex
glomerulus
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Blood leaves the glomerular capillaries and enters ______(smaller in diameter)
Efferent arterioles
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Efferent arteioles branch into a capillary network called ____________
Peritubular capillary system
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Blood flow through the peritubular system is under ______ pressure
low
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Network of capillaries that surround various portions of the renal tubule
peritubular capillary system
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Portion of the peritubular system that dips into the renal medulla and back, supplies the loop of Henle, and is associated with Juxtamedullary nephrons
Vasa Recta
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Single vein that exits kidney at hilum and empties into inferior ven cava
renal vein
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Functional unit of the kidney
nephron
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A single nephron is consists of a ______ and a ______
- renal corpuscle
- renal tubule
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Where would the glomerulus and bowman's capsule be found?
renal corpuscle
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Double layered cup at the end of a renal tubule that recieves fluid filtered in the glomerulus
bowman's capsule
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What are the layers of squamos epithelial cells that compose the inner and outer layer of the bowman's capsule?
- Parietal layer(outer)
- Visceral layer(Inner)
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Which layer of the bowman's capsule directly covers the glomerulus and is composed of podocytes?
Visceral
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Highly modified epithelial cells with little feet
podocytes
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Secondary processes of podocytes that embrace capillaries of the glomerulus
pedicals
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Narrow spaces that lie between pedicals
slit pores
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Can the pedicals from one podocyte embrace more than one glomerular capillary?
yes
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Renal tubule continues from ______
bowman's capsule
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Sequnce of strucures in the renal tubule
- proximal convoluted tubule(PCT)
- Nephron Loop(Loop of Henle)
- Distal Convoluted Tubule (DCT)
- Collecting duct
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Located in renal cortex, lined with simple cubodial or columnar epithelium, contains microvilli, large cells, quite coiled
PCT
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Thick then thin descending limbs(similar to PCT) that penetrate into pyramids of the renal medulla
descending loop of henle
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thin ascending and then thick ascending limbs(similar to DCT)
ascending loop of henle
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Thin limbs of the loop of henle are composed of _______
squamos epithelium
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Thick limbs of the loop of henle are composed of ___________
cuboidal epithelium
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Terms that refer to the height of the epithelium of the nephron loop
thick and thin
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Located in the Renal cortex, coiled but shorter than PCT, lined with cuboidal epithelium, NO microvilli,smaller cells with large lumens
Distal Convoluted tubule (DCT)
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Part of collection system that empties urine into minor calyox through renal papilae, straight tubule joined by several merging DCT
collecting duct
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Consists of juxtaglomerular cells and macula densa
juxtaglomerular apparatus
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Located at the point of contact between DCT and afferent and efferent artireioles of its parent nephron
juxtaglomerular apparatus
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Cells of macula densa are sensitive to what ion content of tubular fluid?
chloride
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Modified wall segment of DCT where cells become columnar
macula densa
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What cells produce renin?
juxtaglomerular cells
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Renin is secreted whenever the B/P in the afferent arterioles ______
drops
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Cells found in the tunica media of the afferent arteriole near attachment to glomerulus
juxtaglomerular cells
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What are the 2 types of nephrons found in the kidney?
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Which nephrons are more numerous, with short loop of henle that dont' reach the medulla
cortical
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Which nephrons have their renal corpuscules located in the renal cortex, near the kidney surface?
cortical
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Which nephrons have their renal corpuscules near the medulla, long loops of henle, and are important in concentrating urine?
juxtamedullary
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Removes waste from the blood and regulate water and electrolyte concentrations
nephrons
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openings in the glomerular capillaries that make them more permeable
fenestrae
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water, ions, and dissolved materials are filtered out of glomerular capillary and into glomerular capsule
glomerular filtration
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Glomerular filtration is mostly due to ______
filtration pressure, caused by hydrostatic pressure of blood in glomerular capillaries
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What 2 forces oppose the filtration
- collioid osmotic pressure(plasma)
- capsular hydrostatic pressure(bowma's capsule)
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Opposing filtratin source(during glomerular filtration) that is due to the presence of proteins, creates a drawing force, causing water returns to plasma of glomerular capillaries
colliod osmotic pressure
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Would colloid osmotic pressure occur in the bowman's capsule?
No
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Opposing filtratin source(during glomerular filtration) that is due to the resistance of the water and solutes to flow into the capsule due to fluid already being present
capsular hydrostatic pressure
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An increase in either of the opposing forces during glomerular filtration would _____ filtration
reduce
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Fluid received by the bowman's capsule, similar to tissue fluid, lacks proteins
filtrate
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Kidneys produce _____ ml of glomeular fluid per minute and ______ L per day
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Glomerular filtration rate is proportionate to
filtration pressure
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Vascoconstriction of an effernet arteriole would ______ glomerular hydrostatic pressure, which would increase GFR
increase
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How is filtration rate regulated in the kidneys?
autoregulation
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Filtration rate is influenced by the ______ nervous system
sympathetic
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If blood pressure and volume decrease the SNS would ______ the afferent arterioles, which would _____ GFR, therby ______ urine formation
- vasoconstrict
- decrease
- decerase
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If there were excess body fluids in the system the SNS would cause _____ of the afferent arterioles, which would ____ GFR, therby _____ urine output
- vasodilate
- increase
- increasing
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Where is renin secreted?
juxtaglomerular cells
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Renin is released in response to stimulation from SNS and renal _____(in the afferent arterioles) when B/P _____
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When sodium, potassium, and chloride ions are low in the tubular fluid the ____ _____ will also stimulate the release of renin
macula densa
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Renin splits ______ to create _______
- angiotensinogen
- angiotensin I
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What enzyme converts angiotensin I to angiotensin II? Where is this enzyme concentrated?
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Most potent vasoconstictor of the body?
angiotensin II
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Angiotensin II stimulates the release of ______ from the ____ _____
- aldosterone
- adrenal cortex
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aldosterone release:
______ sodium reabsorption
______ urine output
_____ Blood volume and B/P
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What hormone will be released from the atria when it is streached due to high blood volume and B/P?
atrial natriuretic peptide(ANP)
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inhibits release of renin and aldosterone, helps return B/P to normal
atrial natriuretic peptide(ANP)
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What portion of the nephron is effected by the release of aldosterone?
DCT and collecting duct
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Where does most reabsorption happen on the nephron?
PCT
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