kawasaki disease and immunizations

acute systemic vasculitis of unknown origin, assoc w spring cleaning

infants and young children (18mo-5 yrs is pk incidence)

• season-more common in winter or spring
• possible infectious cause
• race-originally found in asian pts but affects all

• fever, bilateral nonexudative conjunctivitis
• erythema of lips and oral mucosa
• changes in extremities
• rash-usually on extre
• cervical lyphadenopathy

• fever for five or more days
• four or more of the following (5):
• changes in extrem
• rash-skin peels off
• conjunc
• cracking of lips and oral cavity, strawberry tongue
• cervical lymphadenopathy

• reducing inflamm of coronary artery wall
• preventing coronary thrombosis

preventing myocardial ischemia and infarction in those that develop aneurysms, tx all w possible diag

• IVIG-2gm/kg in a single inf(fever should come down rapidly)
• asa-80-100mg/kg/d in 4 doses during acute , dec to 3-5 mg/kg/d until follow up shows no coronary artery changes at 6-8 wks after onset of illness

coronary artery aneurysms primarily in untreated children

provides details related to compensaion if injury occurs

removes manufactureres from liability if injuries occur as long as full info regatding product is provided

FDA must be notified within 7 days if an adverse rxn does occur

manufacturer, lot, date of admin, name, address, title of person giving