Analgesic Meds

• Uses: Severe pain, sedation, pain & anxiety of AMI, acute pulmonary edema
• -analgesic, narcosis

• ADE: Peripheral vasodilation, nausea, constipation, CNS depression, Miosis, blur (due to parasympathetic)
• -tolerance and addiction can occur
• -CYP 450 inducer

Uses: analgesic, narcosis

• ADE: CNS depression, sedation, cardiac changes, dizzy, itchy, constipation, nausea, urinary retention, blur, diplopia, miosis, nystagmus.
• -tolerance and addiction can occur

Uses: moderate to severe pain

• ADE: CNS depression, sedation, cardiac changes, dizzy, itchy, constipation, nausea, urinary retention, blur, diplopia, miosis, nystagmus.
• -Dependence can occur

Uses: Moderate pain - alternative to Codeine

• ADE: CNS depression, sedation, cardiac changes, dizzy, itchy, constipation, nausea, urinary retention, blur, diplopia, miosis, nystagmus.
• -Dependence can occur
• -used under co-mgmt of surgery & trauma to the eye.

• Pro-drug, 10% metabolized to morphine.
• Uses: moderate pain, anti-tussive agents.
• -combined with APAP or ASA for analgesic synergy.

• ADE: CNS depression, rash, dizzy, itchy, constipation, nausea, blur, diplopia.
• -Dependence can occur

• More potent than marphine
• Uses: preoperative/anesthetic agents, severe pain

• ADE: CNS depression, sedation, cardiac changes, dizzy, itchy, constipation, nausea, urinary retention, blur, diplopia, miosis, nystagmus.
• -Dependence can occur

MOA: Binds to Mu-opiate receptors in the CNS & cause inhibition of ascending pain pathways.

Uses: Moderate to severe chronic pain. (PO only)

• ADE: HA, sedation, dizzy, itchy, constipation.
• -doses adjusted for renal/hepatic dysfunction

Uses: Mild/moderate pain, fever reducer, reduces inflammation, reduces blood clotting, uricosuric agent.

MOA: Inhibits synthesis of prostoglandins in the CNS and Peripherally blockspain impulse generation, inhibits hypothalamic heat-regulating center.

Uses: mild-moderate pain, reduces fever. (no anti-inflammatory effects)

• ADE: Metabolized hepatically (overdose can cause hepatotoxicity-most common for accidental toxicity)
• -Don't exceed 3gm/day - FDA

Uses: Migrane Tx (vasoconstiction to reduce inflammation)

ADE: Inc BP, chest pain, Palpitations, vasospasm, dizzy, drowsy, abdominal pain.

-cautions in persons with coronary artery disease.