-
The ____ ___ keeps us from getting respiratory infections
Mucociliary escalator
-
What are the 2 components of the mucociliary escalator
Mucus and cilia
-
In the mucociliary escalator, ___ traps the virus and ___ sweepts it out
Mucus, cilia
-
What are 3 things that paralyze the mucociliary escalator
Tobacco smoke, alcohol, narcotics
-
___ and ____ interfere with cilia, making users predisposed to respiratory infection
alcohol and tobacco
-
Mucus is produced by ___ cells
Goblet
-
Which are more serious? Upper or lower respiratory tract infections
Lower
-
What are EENT infections
Eye, ear, nose, throat
-
Pain, fever, and difficulty with swallowing are symptoms of ____ ___ ____
Streptococcal sore throat
-
A symptom of strep throat is red throat, with patches of ___
Pus
-
Strep throat is usually not associated with ___ or ___ ___
Cough, runny nose
-
S. pyogenes is part of group ___ strep
A
-
Group A strep virulence factors includes ___ peptidase.
C5a
-
In group A strep, the ___ ___ capsule mimics self antigen
Hyaluronic acid
-
In group A strep, the _ protein contains __ protease, and is the antigen responsible for late sequelae
M, C3b
-
In group A strep, ___ dissolves blood clots
Streptokinase
-
In group A strep, streptokinase helps the virus ___ easier in the blood, and can also act as a blood thinner or ___
Penetrate, anticoagulate
-
Exotoxins, hemolysins, streptokinase, M and G proteins, hyaluronic acid and C5a peptidase are virulence factors of ___
Group A strep
-
In group A strep, the G protein has an ___ binding protein
Fc
-
Acute rheumatic fever is a late sequelae of ___
Strep throat
-
In acute rheumatic fever, antibodies are made against the ___ protein
M
-
In acute rheumatic fever, antibodies erode valves, helping ___ attach
Biofilms
-
In acute rheumatic fever, viridians (which are ___) can colonize the heart valve
Normal mouth flora
-
When normal mouth flora colonize the heart valve, it is called subacute bacterial ____
Endocarditis
-
In acute rheumatic fever, antibodies erode valves by recruiting ___ cells and the ___
NK, complement system
-
In acute rheumatic fever, the antibodies elicit a type ___ hypersensitivity response
II
-
Corynebacterium diphtheriae have an __ toxin
AB
-
Low __ in hosts is a sign that diphtheria is in the body
Fe
-
Diphtheria produces ___ that ?steal? hosts? Fe
Lactoferrin
-
In diphtheria, the __ part of the toxin binds to receptors on heart, kidneys, and throat
-
In diptheria, the A part of the toxin stops __
Protein synthesis
-
__ may cause heart failure by killing heart cells
diptheria
-
a ___ forms from dead cells in the throat, blocking the airway
pseudomembrane
-
diptheria spreads by ___
respiratory droplets
-
diphtheria may have __ carriers
asymptomatic
-
you should get a diphtheria vaccine if youre travelling to __
Russia
-
Diphtheria is treated with an ___
Antitoxins
-
Antitoxins are (passive/active?) immunity
Passive
-
__ and ___ are vaccines for diphtheria
DTaP and DPT
-
A common name for bacterial conjunctivitis is __
Pinkeye
-
Haemophilus influenzae type B (Hib), strep pneumonia, neusseria gonorrhoeae, and pseudomonas are organizations that may cause ___
Bacterial conjunctivitis
-
Pseudomonas that cause pinkeye may be present in contaminated __
Cosmetics
-
If pus is associated with pinkeye, it is a (bacterial/viral?) infection
Bacterial
-
A common name for otitis media is ___
Ear infection
-
Haemophilus influenzae type b (Hib) and strep pneumoniae are 2 organisms that may cause __ and __ infections
Ear and eye
-
Haemophilus (Hib) and strep pneumoniae may travel through the Eustachian tube from the pharynx, where they are normally __
Native flora
-
Headache, swelling, and pus in nasal secretions are symptoms for __
Sinusitis
-
Same bacteria that cause sinus infections may also cause __ and __ infections because they are all connected
Ear and eye
-
The same bacteria can cause eye, ear, and nasal infections because they are all connected by __ and __
Tear ducts, eustachian tube
-
Hib may cause bacterial conjunctivitis, otitis media, and ___
Meningitis
-
Strep pneumoniae is a (lower/upper) respiratory tract infection
Lower
-
The most common of community-acquired bacterial pneumonia is __
Strep pneumoniae
-
In a ___ infection, the lungs are filled with liquid
Strep pneumoniae
-
High fever and exudate from pneumonia are caused by an immune response by the ___ and ___
PMNs and diplococci
-
High fever and acute shortness of breath are associated with __
Pneumonia
-
For pneumonia, a _-valent vaccine is available for adults and __-valent for kids
23, 7
-
the common cold is caused by __
rhinovirus
-
rhinovirus is a __virus
picorna
-
the __ is a naked, ssRNA
rhinovirus
-
the ___ is a naked, dsDNA
adenovirus
-
the rhinovirus can survive the acidity of the ___ but not of the __
upper respiratory tract, stomach
-
the rhinovirus only spreads by ___
respiratory droplets
-
the rhinovirus binds to __ cell receptors
epithelial
-
after the rhinovirus binds, cell death induces ___ mediators, causing secretions and swelling
immune
-
___ causes the most common infectious disease
rhinovirus
-
There are more than __ different rhinoviruses
100
-
pleconaril is a new drug to treat ___
rhinovirus/common cold
-
pleconaril binds to ___
capside
-
pleconaril inhibits ___ binding
receptor
-
a cold with a fever is caused by ___
adenovirus
-
___ can survive in stomach acid, but __ cannot
adenovirus, rhinovirus
-
___ can be spread fecally, but __ cannot
adenovirus, rhinovirus
-
some strains of ___ can cause diarrhea
adenovirus
-
the treatment for adenovirus is usually just for ___
symptoms
-
a sore throat can be caused by both __ and ___
adenovirus, streptococcus
-
a sore throat from ___ is much worse than from __
streptococcus, adenovirus
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