Neuropath - Dementia and Degeneration

Diffuse cortical atrophy as commonly seen in Alzheimer's Disease

Alzheimer's Disease

Granulovacuolar bodies as seen in Alzheimer's Disease

Hirano Body as seen in Alzheimer's Disease

• Silver stain demonstrating plaques and tangles as seen in Alzheimer's Disease
• Tangles have a "flame-shaped" appearance
• Plaques look like "burned-out camp fires"

GranulovacularDegeneration small cytoplasmic vacuoles with a single granule

Hirano Bodies as seen in AD

• Alzeheimer's Disease
• Neurofibrillary Tangle

"spikey ball" pathology seen in Kuru

Spngiform changes typical for CJD

Pulvinar hyperintensity commonly seen in CJD

Putamenal hyperintensity seen in CJD

Lewy Bodies typical of Dementia with Lewy Bodies

Knife-edged pattern of gyral atrophy typical for Pick's Disease

SIlver stain showing Pick Bodies and Tangles

Neuromelanin accumulations as seen in progressive supranuclear palsy

Loss of dopaminergic neurons in the substantia nigra as seen in Parkinson's Disease

Atrophy of the caudate as seen in Huntington Disease

Gross spongiosis as can be seen in CJD

White matter changes sparing the U-fibers as can be seen in leukodystrophies like Karabbe, Metachromatic, and Adrenoleukodystrophy.

NOTE: Canavans and Alexanders affect the U-fibers.

Cresyl Violet stain showing brown discoloration of Myelin seen in MLD

Spongiform changes seen in Canavan’s Disease which are similar to CJD

Rosenthal Fibers which are eosinophilic astroytic inclusions also seen in PikocyticAstrocytomas