Top 30 Hospital drugs.txt

  1. Lovenox
    • Gen: Enoxaparin Sodium,
    • Class: Anticoagulant (LMW-heparin),
    • RoA: IV,
    • MOA: Anti-Factor Xa and anti-thrombin (Factor IIa) activity,
    • Indication: DVT, PE, MI, Ischemia, (all postop and prophylaxis)
  2. Aranesp
    • Gen: Darbepoetin Alfa,
    • Class: Erythropoietic- Hematopoietic,
    • RoA: IV or SC,
    • MOA: stilmulates progenitor stem cells for production/differentiation of erythropoiesis,
    • Indication: Anemia from Chronic Kidney Disease and Chemotherapy
  3. Procrit
    • Gen: Epoetin Alfa,
    • Class: Erythropoietic- Hematopoietic,
    • RoA: IV or SC,
    • MOA: stimulates bone marrow division/differentiation of committed erythroid progenitors,
    • Indication: Anemia from Chronic renal failure, Chemotherapy, or Surgical procedures
  4. Revlimid
    • Gen: Lenalidomide,
    • Class: Immune Modulator (antiangiogenetic),
    • RoA: Oral,
    • MOA: inhibits cell proliferation, pro-inflammatory cytokines,
    • Indication: Multiple myeloma, Myelodysplastic syndrome
  5. Neulasta
    • Gen: Pegfilgrastim,
    • Class: Colony Stimulating Factor(CSF), Hematopoietic,
    • RoA: SC,
    • MOA: A CSF- stimulates proliferation/differentiation/ activation of hematopoietic cells,
    • Indication: Febrile neutropenia, in pt with non-myeloid malignancies, Prophylaxis
  6. Remicade
    • Gen: Infliximab,
    • Class: Immunosuppressant (TNFa-I),
    • RoA: IV infusion,
    • MOA: inhibits the binding of TNF alpha,
    • Indication: Crohn's, Colitis, RA, psoriasis
  7. Rituxan
    • Gen: Rituximab,
    • Class: Antineoplastic agent, (Mab),
    • RoA: IV infusion,
    • MOA: binds to CD20 antigen located on pre-B lymphocytes and may promote lysis,
    • Indication: Lymphomas, Leukemias, RA
  8. Levaquin
    • Gen: Levofloxacin,
    • Class: Antibiotic (fluoroquinolone),
    • RoA: Oral , IV, optical,
    • MOA: inhibits topoisomerase IV, DNA gyrase (replication, transcription, repair, recombination),
    • Indication: Bronchitis, Pneumonia, UTI, (Anthrax)
  9. Avastin
    • Gen: Bevacizumab,
    • Class: Immunomodulator, Antiangiogentic, (Mab) VEGF-I,
    • RoA: IV infusion,
    • MOA: IgG1 antibody Binds to VEGF to inhibit VEGF/Flt1 & KDR interaction of epithelial cells
    • Indication: Glioblastoma, Cancer (Colorectal, Renal cell Small cell lung)
  10. Zosyn
    • Gen: Piperacillin Sodium/Tazobactam Sodium,
    • Class: Antibiotic (antipseudomonal/B-lactamase-I),
    • RoA: IV infusion,
    • MOA: Transpeptidase-I/ B-lactamase-I ,
    • Indication: Appendicitis, Pneumonia, Skin infection, Peritonitis, Puerperal endometritis
  11. Neupogen
    • Gen: Filgrastim,
    • Class: Colony Stimulating Factor, Hematopoietic,
    • RoA: SC,
    • MOA: granulocyte CSF, regulates neutrophil production, progenitor proliferation, and differentiation,
    • Indication: Febrile neutropenia, harvesting peripheral stem cells
  12. Eloxatin
    • Gen: Oxaliplatin,
    • Class: Antineoplastic Agent, Platinum Coordinating Complex
    • RoA: IV,
    • MOA: binds nucleotides to inhibit DNA replication of tumor cells
    • Indication: Colon cancer - stage III, colorectal cancer
  13. Diprivan
    • Gen: Propofol,
    • Class: Sedative/Hypnotic, Anesthetic,
    • RoA: IV,
    • MOA: unknown,
    • Indication: General anesthesia, Sedation for mechanically ventilated
  14. Omnipaque
    • Gen: Iohexol,
    • Class: (dye)Non-Ionic Contrast Agent,
    • RoA: IV,
    • MOA: hypotonic, low osmolality to serum,
    • Indication: Diagnostics radiology
  15. Integrilin
    • Gen: Eptifibatide,
    • Class: Anticoagulant, Glycoprotein-I (2b/3a)
    • RoA: IV,
    • MOA: inhibits platelet aggregation by binding to GP2b/3a - prevents binding of fibrinogen, vWf, and other adhesive ligand,
    • Indication: Acute coronary syndrome, percutaneous coronary intervention
  16. Advair Diskus
    • Gen: Fluticasone Propionate/Salmeterol Xinafoate,
    • Class: Antiasthma, Anti-inflam/Bronchodilator Combo,
    • RoA: Inhalation,
    • MOA: Fluticasone: glucocorticoid receptor agonist. Salmeterol: long acting beta agonist, relaxes bronchial smooth muscles,
    • Indication: Asthma, COPD
  17. Sodium Chloride
    • Gen: Sodium Chloride,
    • Class: Dermatological Agent, Parenteral Electrolyte, Sodium Supplement,
    • RoA: Inj, IV, Topical,
    • MOA: principle cation of extracellular fluid,
    • Indication: Corneal edema, Elective abortion, Heat stroke, Hyponatremia, Hypovolemic shock, Nasal irritation
  18. Zyvox
    • Gen: Linezolid,
    • Class: Antibiotic (Oxazolidinone),
    • RoA: IV
    • MOA: inhibits ribosomal translation by binding to 23S of 50S RNA, Preventing 70S complex formation
    • Indication: Pneumonia, Vanco-resistant Enterococcus faecium infection, infection of skin
  19. Herceptin
    • Gen: Trastuzumab,
    • Class: Antineoplastic Agent, Mab (HER2-I),
    • RoA: IV,
    • MOA: monoclonal antibody binds to HER2 protein to inhibit the growth of tumor cells,
    • Indication: Metastatic breast cancer, HER2 overexpression
  20. Protonix
    • Gen: Pantoprazole Sodium,
    • Class: PPI,
    • RoA: Oral, IV
    • MOA: inhibits acid secretion by covalently binding to the H/K ATPase pump,
    • Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
  21. Taxotere
    • Gen: Docetaxel,
    • Class: Antineoplastic Agent (Mitotic-I),
    • RoA: IV,
    • MOA: binds/inhibits microtubule disassembly inhibiting mitotic/interphase = no cell division,
    • Indication: Breast cancer, Gastric cancer, Head & neck cancer, hormone refractory prostate cancer, lung cancer
  22. Angiomax
    • Gen: Bivalirudin,
    • Class: Anticoagulant, Thrombin-I,
    • RoA: IV,
    • MOA: binds to catalytic site and the anion-binding exosite of circulating and clot-bound thrombin,
    • Indication: Heparin-induced thrombocytopenia, Thromboembolic disorder
  23. Thrombin-jmi
    • Gen: Bovine Thrombin,
    • Class: Hemostatic, Coagulant,
    • RoA: Topical,
    • MOA: a protein substance that immediately clots the fibrinogen of the blood,
    • Indication: hemorrhage
  24. Cancidas
    • Gen: Caspofungin Acetate,
    • Class: Antifungal, Glucan Synthesis I,
    • RoA: IV,
    • MOA: inhibits beta-1,3-D-glucan synthesis: an important component of cell wall,
    • Indication: Aspergillosis, Candidemia, Febrile neutropenia
  25. Ultane
    • Gen: Sevoflurane,
    • Class: Anesthetic, Haloalkane,
    • RoA: Inhalation,
    • MOA: disrupts lipid matrix of neuronal membranes affecting gating of ion channels,
    • Indication: General Anesthesia
  26. Seroquel
    • Gen: Quetiapine Fumarate,
    • Class: Antipsychotic, Dibenzothiazepine,
    • RoA: Oral,
    • MOA: antagonist of 5-HT1A, 2, D1,2, H1, and alpha1,2,
    • Indication: Bipolar-1, MDD, Schizophrenia
  27. Protonix IV
    • Gen: Pantoprazole Sodium,
    • Class: PPI,
    • RoA: Oral, IV
    • MOA: inhibits acid secretion by covalently binding to the H/K ATPase pump,
    • Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
  28. Gemzar
    • Gen: Gemcitabine Hydrochloride,
    • Class: Antineoplastic Agent, Antimetabolite
    • RoA: IV,
    • MOA: nucleoside analogue cell phase-specific for the S-phase and for the G1/S-phase, inhibits DNA synthesis,
    • Indication: Breast, Ovarian, Pancreas, non-small cell lung cancers
  29. Erbitux
    • Gen: Cetuximab,
    • Class: Antineoplastic agent, (Mab) EGFR-I,
    • RoA: IV,
    • MOA: binds EGFR blocking phosphorylation/activation of kinases, inhibiting growth/survival of tumor cells
    • Indication: Head and neck cancer, Metastatic colorectal cancer
  30. Visipaque
    • Gen: Iodixanol,
    • Class: (Dye)Non-Ionic Contrast Agent
    • RoA: IV,
    • MOA: hypotonic, low osmolality to serum,
    • Indication: Diagnostics Radiography
Card Set
Top 30 Hospital drugs.txt
Brand to generic with class, RoA, MOA and indication