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What are the functions of blood?
- helps maintain the stability of the interstitual fluid
- distributes heat
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What is the composition of blood?
- cells
- cell fragments
- dissolved biochemicals
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percentage by volume of red blood cells in a sample of whole blood
hematocrit
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production of blood and blood cells
hematopoiesis
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tiny
biconcave discs
thin near their centers
thicker around their rims
characteristics of mature red blood cells
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oxygen carrying pigment in red blood cells
gives the color to blood cells
Hemoglobin
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compound formed when oxygen binds hemoglobin
oxyhemoglobin
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hemoglobin that does not bind oxygen
deoxyhemoglobin
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a red blood cell at an immature stage
erythroblast
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immature red blood cell that has a network of fibrils in ints cytoplasm
reticulocyte
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kidney hormone that promotes red blood cell formation
controls the rate of red blood cell formation
erythropoietin
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What are the dietary factors affecting erythrocyte (RBC) production?
b12, iron and folic acid
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deficiency of red blood cells or a reduction in the amount of hemoglobin they contain resulting in a condition called _______?
anemia
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caused by toxic chemicals and radiation.....causes damaged bone marrow
aplastic anemia
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caused by toxic chemicals and the red blood cells are destroyed
hemolytic anemia
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caused by a lack of dietary anemia....causes a hemoglobin deficiency
iron deficiency anemia
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inability to absob vitamin b12....causes an excess of immature cells
pernicious anemia
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nucleus with 2-5 lobes....phagocytizes small particles
neutrophil
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nucleus bilobed....kills parasites and moderates allergic reactions
eosinophil
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nucleus lobed...releases heparin and histamine
basophil
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2-3 times larger then a red blood cell....phagocytizes large particles
monocyte
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only slightly larger than a red blood cell.....provides immunity
lymphocyte
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What is the approximate normal leukocyte count?
4,500-10,000 per microliter
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leukocytes can squeeze between the cells that form the walls of the smallest blood vessels.....allows the white blood cells to leave the circulation
diapedesis
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a total number of white blood cells exceeding 10,000 per microliter of blood constitutes _____?
leukocytosis
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a total white blood cell count below 4,500 per microliter of blood is called
leukopenia
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List some disorders that alter the different white blood cells
- allergies
- bacterial infections
- parasitic infection
- HIV & AIDS
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are not complete cells...arise from very large cells in the red bone marrow...helps blood clot
platelets/thrombocytes
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low number of platelets in the circulating blood
thrombocytopenia
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is the presence of high platelet counts in the blood
thrombocytosis
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contracts smooth muscles in the vessel walls, reducing blood flow
serotonin
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Which substances are found in plasma?
- 92% water
- organic and inorganic biochemicals
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plasma protein that helps maintain colloid osmotic pressure
albumin
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transports lipids and fat-soluble vitamins...constitute the antibodies of immunity
globulins
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plays a key role in blood coagulation
fibrinogen
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Which lipids are found in plasma?
- triglycerides
- phospholipids
- cholesterol
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List the nonprotein nitrogenous substances in plasma
- amino acids
- urea
- uric acid
- creatine
- creatinine
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refers to the stoppage of bleeding, which is vitally important when blood vessels are damaged
hemostasis
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platelets adhere to exposed ends of injured blood vessels
platelet plug formation
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triggered when blood contacts damaged blood vessel walls or tissues outside blood vessels
extrinsic clotting mechanism
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activation of Hageman factor....this happens when blood is exposed to a foreign surface such as collagen in connective tissue instead of the smooth endothelial lining of intact blood vessels
intrinsic clotting mechanism
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this test chekcs the extrinsic clotting mechanism
prothrombin time test(PT)
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this test evaluates intrinsic clotting
partial thromboplastin test(PTT)
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a blood clot abnormally forming in a vessel
thrombus
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a clot that dislodges or a fragment of a clot that breaks loose and is carried away by the blood flow
embolus
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used to prevent abnormal clotting
heparin and coumadin (warfarin) therapy
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chemical that stimulated B lymphocytes to produce antibodies
antigens
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protein that B cells of the immune system produce in response to a nonself antigen...it reacts with the antigen
antibodies
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What is the major concern with blood transfusions?
that the cells in the donated blood not clump due to antibodies in the recipients plasma
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abnormal hemoglobin crystallizes under low oxygen conditions, causing abnormal red blood cells which block ciculaion causing anemia, pain, anf other symptoms
sickle cell anemia
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