-
Solvolysis/hydrolysis drugs (5)
- Aspirin
- Tetracaine
- Procaine
- Penicillin
- Cephalosporin
-
Hydrolysis strategies (5)
- Desicant packets (tablets)
- Replace solvent (liquids)
- Micelles (liquids)
- Buffer pH (liquid)
- Store as a dry powder (liquid)
-
Oxidation-Reduction drugs (4)
- Vitamin C
- Epinephrine
- Morphine
- Phenothiazines
-
Oxidation-Reduction strategies (5)
- Purge O2 from container
- Buffer pH
- Store at lower temp
- Chelating agents(EDTA, citric acit, tartaric acid)
- Antioxidants(sulfites, ascorbic acid, thioglycolic acid, vitamin E, butylated hydroxytoluene)
-
Chelating agents (3)
EDTA, citric acit, tartaric acid
-
Antioxidants (6)
sulfites, ascorbic acid, thioglycolic acid (water soluble)
vitamin E, butylated hydroxytoluene (lipid soluble)
-
Photolysis drugs (2) and strategies (2)
- Riboflavin
- Phenothiazines
- Amber bottles
- Coat tablets with UV absorbing film
-
Racemization drugs (2) and strategies (4)
- Epinephrine
- Tetracycline (epimerization)
- Store at lower temps
- Change the solvent
- Remove catalysts
- Protect from light
-
Isomerization drugs (2) and strategies (4)
- Vitamin A
- Betamethasone 17-valerate
- Store at lower temps
- Change the solvent
- Remove catalysts
- Protect from light
-
Adsorption drugs (3) strategies (2)
- Nitroglycerin
- Insulin
- Diazepam
- Use glass containers
- Change to tablets
-
Lapinski's rule of 5 for poor oral absorption (4)
- More than 5 hydrogen bond donors
- More than 10 hydrogen bond acceptors
- Molecular weight > 500
- Log P > 5
-
Cosolvents (4)
- Ethanol
- Propylene Glycol
- Polyethylene Glycol
- Glycerin
-
Preservatives (8)
- 85% W/V sugar solutions
- Alcohol
- Benzyl alcohol
- Phenols
- Benzoic acid
- Sodium benzoate
- Sorbic acid
- Parabens
- Benzalkonium chloride
-
Sweetners (5)
- Sucrose
- Aspartame
- saccharin
- sorbitol
- corn syrup
-
Flavorants (4)
- Methylsalicylate
- Peppermint oil
- Wild cherry
- Vanilla
-
Colorants (3)
- Ferric oxide
- Titanium oxide
- Carbon black
-
pH Buffers (3)
- Citric acid/sodium citrate
- Acetic acid/sodium acetate
- phosphate buffers
-
-
Viscosity inducing agents (8)
- Acacia gum
- Xanthan gum
- pectin
- locust bean gum
- methyulcellulose
- carboxymethylcellulose
- hydroxypropyl cellulose
- carbomers
-
-
Cationic surfactants (2)
- cetyl trimethyl ammonium bromide,
- benzalkonium chloride
-
-
Amphoteric surfactant (1)
Lecithin
|
|
