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What is the function of carbohydrates?
- Primary energy source - cellulose (polysaccharide)
- Fibre, starch (polysaccharide) energy storage in plants
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What is the function of lipids?
Primary energy storage in animals; aid in vitamin absorption; insulation; component of cell membrane; making some other chemicals.
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What is the function of protein?
- Functional (ie enzymes building, breaking and rearranging molecules; hemoglobin)
- Structural (ie collagen making up bone and tendons)
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What are the subunits of carbohydrates?
Monosaccharides (general formula of 1C:2H:1O)
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What are the subunits of lipids?
Glycerol and fatty acids
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What are the subunits of protein?
- Aminal acids (8 essential)
- Polypeptides (short chains of amino acids)
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What are examples of carbohydrates?
- Monosaccharides: glucose, lactose, galactose
- Disaccharides: sucrose, lactose, maltose
- Polysaccharides: starch/amylose, cellulose, glycogen
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What are examples of lipids?
- Triglycerides
- Unsaturated fatty acids (double bond between carbon atoms; bent shape; liquid at room temp)
- Saturated fatty acids (single bonds between carbon atoms; straight shape; solid at room temp)
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What are examples of protein?
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Where does digestion of carbohydrates start?
Mouth
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Where does digestion of lipids start?
Small intenstine (duodenum)
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Where does digestion of protein start?
Stomach
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What enzymes digest carbohydrates?
Saliva contains amylase for breaking down amylose/starch; maltase breaks down maltose
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What enzymes digest lipids?
- Lipase breaks apart triglycerides
- Bile salts break large fat globules into small fat globules
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What enzymes digest protein?
- Pepsin (stomach)
- Trypsin (small intestine)
- Peptidases (small intestine) breaks down polypeptides into amino acids
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Define denature
When proteins change shape at high temperatures
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Define substrate
A molecule upon which an enzyme acts
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Define active site
The place on an enzyme where a substrate attaches
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Define functional group
Clusters of atoms that give compounds specific characteristics
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Describe mouth
- Ingestion and digestion
- Physical digestion uses teeth
- Salivary glands secrete saliva which starts chemical digestion and lubricates food
- Tongue moves food around until it forms a bolus
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Describe esophagus
- Ingestion
- Connects mouth to stomach
- Uses peristalsis to move food
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Describe stomach
- Digestion
- Sphincter muscles control the food into and out of the stomach
- Can expand to 1.5L
- Muscular organ contracts/relaxes, churning food
- Mucus lines the stomach protecting tissue from digestive juices
- HCl helps break down food and kill foreign invaders
- Stomach extremely acidic
- Some chemical digestion (pepsin)
- Small amount of absorption
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Describe small intestine
- Digestion and absorption
- Most chemical digestion occurs in the duodenum
- Chyme from stomach enters duodenum
- Pancreatic secretions raise pH of chyme
- Secretions from gallbladder and pancreas aid in chemical digestion
- Villi increase the surface area of small intestine for absorption
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Define duodenum
The first 25cm of the small intestine
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What is chyme?
Partially digested food
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What do villi do?
- Inside each villi is a network of capillaries and lymph vessels
- Monosaccharides and amino acids are absorbed into capillaries
- Glycerol and fatty acids enter lyph vessels
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Describe the liver
- Accessory organ
- Produces bile and bile salts used in lipid digestion
- Stores glucose in the form of glycogen
- Stores vitamins
- Detoxifies harmful substances
- Breaks down hemoglobin
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Describe gallbladder
- Accessory organ
- Stores bile from liver
- Regulates release of bile into the small intestine
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Describe pancreas
- Accessory organ
- Releases chemicals to raise ph of small intestine to a weak base
- Secretes enzymes for chemical digestion
- Other enzymes are released from the small intestine
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Describe large intestine
- Also called colon
- Absorption and egestion
- Absorb water and some minerals
- Feces composed of undigested cellulose, living and dead bacteria and water
- Receptors signal central nervous system when it is time to void wastes
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What regulates blood sugar?
- The pancreas releases hormones that regulate blood sugar
- Insulin lowers blood sugar after a meal
- Glucagon raises blood sugar after exercie
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What happens if blood sugar is not properly regulated?
A person can develop diabetes when the insulin production is not working
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Describe heartburn
- Burning feeling in the lower chest
- Sour or bitter taste in throat or mouth
- Often occurs after a big meal
- Stomach acids irritate the esophagus
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Describe ulcers
Sores in the lining of the stomach caused by the bacterium Helicobacter pylori
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Describe IBS
- Inflammation of the bowel
- Some symptoms include intermittent abdominal pain, constipation, diarrhea, bloating large quantities of gas
- No known cause
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Describe gallstones
- Hardening of cholesterol, bile salts or bilirubin
- Can block ducts that lead to the small intestine
- Can cause inflammation, damage or infection
- Notice when eating fatty foods
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Describe pancreatitis
- Inflammation of the pancreas
- Caused by alcohol abuse, smoking, certain medicines or high levels of triglycerides
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Describe diabetes
- Inability to produce or effectively use insulin
- Symptoms include frequent urination, thirst, weight change, extreme fatigue
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Describe diverticular disease
- Pouches form in the large intestine
- Usually due to a low-fiber diet
- Can lead to inflammation of the colon, pain, fever, nausea or constipation
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Describe esophageal varices
- Fragile, swollen veings at the base of the esophagus
- Caused by disease of the liver
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Describe liver disease
- Often caused by prolonged, excessive alcohol consumption leading to damage to the liver cells and build up of fats in the liver
- May lead to cirrhosis
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Describe hiata hernia
- Weakness in the diaphragm allowing a portion of the stomach to protured into the chest cavity
- Common symptoms include acid reflux
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What are the six major groups of nutrients in the diet?
- Carbohydrates
- Lipids
- Proteins
- Vitamins
- Minerals
- Water
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What is OH
Hydroxyl group
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What are polysaccharides?
- Complex carbohydrates; long chains of monosaccharides
- Examples are starch, glycogen, cellulose and fibre
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What is starch?
Repeating chains of glucose, main energy storage in plants
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What is glycogen?
- Glucose storage in animals
- Long chains of glucose molecules
- Humans store about one days' worth of energy as glycogen in the liver
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What is cellulose?
- The structural component of the plant cell wall; makes them rigid
- Repeating chains of glucose, where every other molecule is flipped
- It passes thruogh the human digestive tract undigested
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What is fibre?
- Undigested parts of fruits, vegetables, grains, nuts and legumes
- May be soluble or insoluble
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What is soluble fibre?
- It is within plant cells, includes pectin, gums and mucilages
- Partly broken down by bacteria in the large intestine, providing energy
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What is insoluble fibre?
- Wheat and corn bran
- Whole grain breads and cereals
- Vegetables
- Fruit skins
- Nuts
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What are saturated fatty acids?
- Only single bonds between carbon atoms
- Form straight chains which fit closely together - tight packing
- Solid at room temperature
- Found in most animal fats
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What are unsaturated fatty acids?
- Have at least one double bond between carbon atoms
- - Monounsaturated - one double bond
- - Polyunsaturated - at least two double bonds
- Bent shape which interferes with packing - loose packing
- Liquid at room temperature
- Found in plant oils, fish oils and margarine
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What is hydrogenation?
- The process of breaking the double bonds between carbons and adding hydrogens
- Converts saturated fatty acids (liquid) into more saturated fatty acids (semisolid)
- Ex. Turning vegetable oil into margarine
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What are minerals?
- Inorganic elements that must b eaten
- Required in small amounts
- You need 22 minerals
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What are examples of minerals?
- Fluoride is used in bone and tooth structure
- Iodine is used in the production of thyroid hormones and regulation of metabolism
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What are vitamins?
- Organic chemicals that the body cannot synthesize
- Some are fat soluble and may be toxic in excess
- Some or water soluble and get flushed from the body and need to be consumed daily
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What is water?
- Important in transporting materials around the body, regulating body temperature, digestion, and keeping skin moist
- Makes up about 55-70% of body weight
- Need to drink 2L per day
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Define catalyst
Substance that speeds up a chemical reaction without being consumed in the process and can be repeatedly used by the same reaction
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Define enzyme
Protein that acts as a catalyst to bring about a specific biochemical reaction
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Define denature
When proteins begin to change at a high temperature
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Define optimal conditions
The conditions that result in the highest rate of reaction
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Define cofactors
- Things that help some enzymes function properly
- May bind to active site or weakly with substrate
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Define substrate
A molecule upon which an enzyme acts
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Define active site
The place on an enzyme where a substrate attaches
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Define critical point
The condition beyond which denaturing occurs/dramatic drop in the rate of reaction
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Define ingestion
Taking in nutrients (eating/drinking)
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Define digestion
Breaking down complex molecules into smaller components (subunits)
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Define absorption
Taking up of digested nutrients from digestive tract into circulatory system for distribution around the body
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Define egestion
Removal of waste from the body
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Amylase
- Found in saliva in mouth
- Amylose becomes maltose
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What enzyme?
Found in saliva in mouth
Amylose becomes maltose
Amylase
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Pepsin
- Found in stomach
- Protein becomes polypeptide
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What enzyme?
Found in stomach
Protein becomes polypeptide
Pepsin
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Trypsin
- Pancreas
- Protein becomes polypeptide
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What enzyme?
Found in pancreas
Protein becomes polypeptide
Trypsin
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Pancreatic amylase
- Pancreas
- Amylose becomes maltose
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What enzyme?
Pancreas
Amylose becomes maltose
Pancreatic amylase
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Peptidases
- Small intestine
- Polypeptides become amino acids
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What enzyme?
Small intestine
Polypeptides become amino acids
Peptidases
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Lipase
- Pancreas
- Triglycerides become glycerol and fatty acids
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What enzyme?
Pancreas
Triglycerides become glycerol and fatty acids
Lipase
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Maltase
- Small intestine
- Maltose becomes glucose
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What enzyme?
Small intestine
Maltose becomes glucose
Maltase
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