Disaccharides easily converted to their monosaccharide bases by what?
enzymes in the digestive tract
Table sugar is most common sugar in what?
plants
Sugar cane and beet are up to how many % by mass sucrose?
20%
What is an enzyme that requires to hydrolyze lactose?
Lactase
What is lack of insufficient amount of the enzyme?
Lactose intolerance
What happens if lactose enters lower GI?
it can cause gas and cramps
Maltose is a product of what?
starch digestion
Where would you find maltose?
-ingredient in infant formulas
-production of beer
-flavoring-fresh baked aroma
Polysaccharides have long chains of more than 10 monosaccharides that equal to what?
polymers of the simple sugars
Where are complex carbohydrates present in?
In most grain products, vegetables and potatoes
At what rate is polysaccharides digested at?
slower rate
What are two most common examples of polysaccharides?
starch and glycogen
What is a polymer of glucose?
Starch
Starch is used by plants to store glucose for what?
later use as energy
What are some common sources of starch?
rice, beans, wheat, corn, potatoes, ect
What happens to starch when eaten?
an enzyme that occurs in saliva and in the intestines break the bonds between the repeating glucose
What is another polymer of glucose?
glycogen
Glycogen is used by animals to?
store energy
Excess glucose is bonded together to form what?
glycogen molecules, which is stored in the liver and muscles tissues as an "instant" source of energy
Glycogen stores excess of this?
glucose
Reducing substances do what?
oxidize or reduce substances
This substances has loss of electrons
Oxidation
This substance gains electrons
reduction
Reducing substances must contain what groups?
aldehyde or ketone group
This is the sum of all the chemical reactions that occur in a cell
Metabolism
What is anabolism?
synthesis of all compounds needed by the cells
What is catabolism?
breakdown of all molecules to obtain energy
What is an enzyme?
is a protein molecule that functions as an organic catalyst to speed a chemical reaction w/out itself being affected by the reaction
amylase, lactase, lipase are examples of what protein molecule?
enzyme
In this process most of ingested carbohydrates are polymers such as starch and glycogen?
digestive process
Digestive process is digestive by what?
salivary amylase and pancreatic amylase=disaccharides
Digestive process is further hydrolysed by what?
maltase, an enzyme released by intestinal mucosa
2 important gut-derived enzymes that hydrolyze what?
sucrase and lactase
Monosaccharides are absorbed by what?
the gut
this is transported to the liver by hepatic portal venous blood supply.
monosaccharides
this is the only carbohydates to be directly used for energy or stored as glycogen
glucose
What must be converted to glucose before use?
fructose and galactose
This is facilitated transport of glucose across the plasma membrane
initial event in glucose metabolism
What happens to glucose once its in circulation?
glucose is taken to the various cells of the body
What happens to glucose within the cells?
is rapidly converted to glucose-6-phosphate, a major intermediate in glucose metabolism
G6P serves as what?
starting point for 4 metabolic pathways
during this process,the cell obtains the high-energy molecule ____
adenosine triphosphate (ATP)
this is energy currency of the cell, mostly gained in mitochondria, and composed of adenosine, ribosome and 3 phosphate groups
adenosine tripohosphate
ATP needs what?
all basic cell functions and the whole body in general
ATP is required to convert glucose to_________ by tissue specific isoenzyme known as _____
glucose 6- phosphate catalyzed, hexokinase
this is a metabolism of glucose to either pyruvate or lactate for production of energy
glycolysis
Whats is the dominant product of aerobic?
pyruvate
This is when oxygen is depleted and lactate is the dominant product
anaerobic
This is glycolytic pathway (Embden-Meyerhof)
Aerobic glycolysis
Prepatory, Krebs cycle, and Citric Acid cycle is also known as?
Tricarboxylic Acid
Aerobic Glycolysis is what type of chain?
Electron Transport
this converts glucose-6-phosphate to two molecules of a three-carbon compound
pyruvic acid
What is produced in the Tricarboxylic Acid cycle?
CO2,NADH, and H
This is a biological pathway that breaks down Acetyl CoA, producing CO2, H+, NADH, FADH2, and ATP
Krebs cycle
This is a waste product that diffuses out of the cells and is given off by the organism.
CO2
This accounts for 2 immediate ATP molecules per glucose molecule
Tricarboxylic acid cycle
In Tricarboxylic both __ and __ will enter the Electron Transport Chain
NADH and FADH2
This occurs in the mitochondria
Electron Transport Chain
Electron Transport Chain is the formation of CO2 and H2O as waste product of what?
glucose metabolism
Electrons move down the chain, carrier are reduced and the ____
oxidized
Energy is captured and used to form what?
ATP
In the END product each glucose molecule yields a net of __-__ ATP molecules(__ from glycolysis, 2 from _____, and 32 or 34 from the electron transport chain, depending on certain conditions.
36-38....2...citric acid
this is important for tissues such as muscle, which often have important energy requirement w/out an adequate oxygen supply
Anaerobic glycolysis
In the absence of oxygen what is pyruvic acid converted to?
lactic acid
Side effects of anaerobic glycolysis are what?
muscles fatigue, pain, cramps, and soreness
This is the most diffused into the bloodstream, then to the liver, where it is converted back to pyruvic acid when oxygen become available
Anaerobic glycolysis
this is a detour of glucose 6 phosphate from the glycolysis pathway to become 6-phosphogluconic acid
Hexose monophosphate shunt (HMP)
this leads to the formation of ribosome-5-phosphate and NADPH
6-phosphogluconic acid
this produces NADPH for the synthesis of fatty acids and steroids for tissues such as mammary glands, adipose tissue, adrenal cortex and the liver
Hexose Monophosphate Shunt
this is very important to RBC's which lack mitochondria
NADPH
NADPH in RBCs help protect what?
the RBC cell membrane and RBC enzymes from the damaging effects of oxidants and free radicals
The HMP also allows the pentose to enter what?
glycolytic pathway
In this metabolic process conversion of glucose to glycogen for storage is what?
Glycogenesis
Glycogenolysis is the breakkdown of what for use as energy?
glycogen to glucose
This process is glycogen broken back down into glucose when energy is needed
Glycogenolysis
Glycogenesis is mediated by what?
enzyme glycogen phosphorylase (phosphate group not water break down the linkage)
What are the major depots of glycogen?
liver and skeletal muscle
Insulin is synthesized by what cells of the Islets of Langerhans in the pancreas?
Beta cells
___is the primary homone responsible for increasing glucose levels and synthesized by the ____ of the Islets of Langerhans in the pancreas?
Glucogon, alpha
This hormone is released during time of stress and increase plasma glucose by inhibiting insulin secretion?
Epinephrine
Released from the adrenal cortex on stimulation by ACTH?
Cortisol or glucorticoid
This hormone is produced by the Delta cells of the Islets of Langerhans of the pancreas?
somatostatin
What are the laboratory findings for the hyperglycemia ?
-increased glucose in plasma and urine
-increased osmolality
-ketones in plasma and urine
-decreased blood and urine PH
-electrolyte imbalance
A group of metabolic diseases characterized by hyperglycemia due to defects in___ secretion, action or both?
insulin...diabetes mellitus
What are the characteristics of DM Type 1?
-10-20% of Diabetes
-Insulin dependecy
-children & adolescences
-sudden onset
-genetic
-ketoacidosis
What are the characteristics of Type 2 DM?
-most common type of diabetes
-obesity
-decrease cell or response
-ketoacidosis is rare
-adult onset
What are some characteristics of Gestational DM?
-pregnant women
-seen in woman over 25
-metabolic & hormonal changes
-glucose returns to normal after birth
What are the 3 criteria's for Diabetes Mellitus?
-fasting glucose
-random glucose
-OGTT
According to ADA,__ of the above criteria must be confirmed on different days.
2
What are normal values for fasting glucose? 2HR OGTT?
-60-110
-<140
What are the signs and symptoms of hypoglycemia?
-dizzyness
-nervousness and shaking
-confusion
-vomiting
-sweating
__primary source of energy for brain, erythrocytes, and retinal cells.
glucose
______,_____,_____ are the basic elements of carbohydrates.
carbon, hydrogen, oxygen
Define glycogenesis
conversion of glucose to glycogen
Define glycogenolysis
breakdown of glucogen to glucose
define Glyconeogenesis
synthesis of proteins to glucose
define hydrolysis
water breaks down sugars
what do hydrolysis of the following diasaccharides yield? sucrose, lactose, maltose
sucrose:glucose+fructose
lactose:glucose+galactose
maltose:glucose+glucose
____is also known as complex carbohydrates
polysaccharides
___ means stored glucose.
glycogen
Insulin is produced by the ___ cells of the ___ in the ___.
beta, Islets, Langerhans
____ produced by the adrenal medulla, during time of stress, increase plasma glucose levels by inhibiting insulin secretion.