Top 20 Hospital Drugs

  1. Lovenox
    • Gen: Enoxaparin Sodium
    • Class: Anticoagulant (LMW-heparin)
    • RoA: IV
    • MOA: Anti-Factor Xa and anti-thrombin (Factor IIa) activity
    • Indication: DVT, PE, MI, Ischemia, (all postop and prohhylaxis)
  2. Aranesp
    • Gen: Darbepoetin Alfa
    • Class: Erythropoietic- Hematopoietic
    • RoA: IV or SC
    • MOA: binds progenitor stem cells stimulating production/differentiation of erthropoiesis
    • Indication: Anemia from Chronic kidney disease and Chemotherapy
  3. Procrit
    • Gen: Epoetin Alfa
    • Class: Erythropoietic- Hematopoietic
    • RoA: IV or SC
    • MOA: bone marrow division/differentiation of committed erythroid progenitors
    • Indication: Anemia from Chronic renal failure, Chemotherapy, or Surgical procedures
  4. Revlimid
    • Gen: Lenalidomide
    • Class: Immune Modulator (antiangiogenetic)
    • RoA: Oral
    • MOA: inhibits cell proliferation, pro-inflammatory cytokines,
    • Indication: Multiple myeloma, Myelodysplastic syndrome
  5. Neulasta
    • Gen: Pegfilgrastim
    • Class: Colony Stimulating Factor (CSF), Hematopoetic
    • RoA: SC
    • MOA: A CSF- stimulates proliferation/differentiation/ activation of hematopoietic cells
    • Indication: Febrile neutropenia, in pt with non-myeloid malignancies, Prophylaxis
  6. Remicade
    • Gen: Infliximab
    • Class: Immunological agent (TNFa-I)
    • RoA: IV infusion
    • MOA: inhibits the binding of TNF alpha
    • Indication: Crohn's, Colitis, RA, psoriasis
  7. Rituxan
    • Gen: Rituximab
    • Class: Antineoplastic agent, (Mab)
    • RoA: IV infusion
    • MOA: binds to CD20 antigen located on pre-B lymphocytes and may promote lysis
    • Indication: Lymphomas, Leukemias, RA
  8. Levaquin
    • Gen: Levofloxacin
    • Class: Antibiotic (fluoroquinolone)
    • RoA: Oral , IV, optical
    • MOA: inhibits topoisomerase IV, DNA gyrase (replication, transcription, repair, recombination)
    • Indication: Bronchitis, nosocomial/comm-acquired pneumonia, UTI
  9. Avastin
    • Gen: Bevacizumab
    • Class: Immunological Agent, (Mab) VEGF-I
    • RoA: IV infusion
    • MOA: recombinant humanized monoclonal IgG1 antibody Binds to VEGF to inhibit VEGF/Flt1 & KDR interaction of epithelial cells to prevent new blood vessels
    • Indication: Glioblastoma, Cancer (Colorectal, Renal cell Small cell lung)
  10. Zosyn
    • Gen: Piperacillin Sodium/Tazobactam Sodium
    • Class: Antibiotic(antipseudomonal/B-lactamase-I)
    • RoA: IV infusion
    • MOA: Transpeptidase Inhibitor/ B-lactamase-I
    • Indication: Appendicitis, Pneumonia, Skin infection, Peritonitis, Puerperal endometritis
  11. Neupogen
    • Gen: Filgrastim
    • Class: Colony Stimulating Factor, Hematopoetic
    • RoA: SC
    • MOA: granulocyte CSF, regulates neutrophil production, progenitor proliferation, and differentiation
    • Indication: Febrile neutropenia, harvesting peripheral stem cells
  12. Eloxatin
    • Gen: Oxaliplatin
    • Class: Antineoplastic Agent
    • RoA: IV
    • MOA: undergoes monoenzymatic conversion
    • Indication: Colon cancer – stage III, colorectal cancer
  13. Diprivan
    • Gen: Propofol
    • Class: Anesthetic, Sedative/hypnotic
    • RoA: IV
    • MOA: unknown
    • Indication: General anesthesia, Sedation for mechanically ventilated (ICU)
  14. Omnipaque
    • Gen: IOHEXOL
    • Class: 2nd gen Nonionic Radiocontrast Agent
    • RoA: IV
    • MOA: low-osmolality intravascular contrast agents
    • Indication: Diagnostic- radiography
  15. Integrilin
    • Gen: Eptifibatide
    • Class: Anticoagulant, Glycoprotein-I,
    • RoA: IV
    • MOA: inhibits platelet aggregation by binding to GP2b/3a à prevents binding of fibrinogen, vWf, and other adhesive ligand
    • Indication: Acute coronary syndrome, percutaneous coronary intervention
  16. Advair Diskus
    • Gen: Fluticasone Propionate/Salmeterol Xinafoate
    • Class: Antiasthma, Anti-inflam/Bronchodilator Combo
    • RoA: Inhalation
    • MOA: Fluticasone – a glucocorticoid receptor agonist. Salmeterol – long acting beta agonist, relaxes bronchial smooth muscles
    • Indication: Asthma, COPD
  17. Sodium Chloride
    • Gen: Sodium Chloride
    • Class: Dermatological Agent, Parenteral Electrolyte
    • RoA: Inj, IV, Irrigation, Nasal, Ophthalmic, Oral, Topical
    • MOA: principle cation of extracellular fluid
    • Indication: Corneal edema, Heat stroke, Hyponatremia, Hypovolemic shock, Nasal irritation
  18. Herceptin
    • Gen: Trastuzumab
    • Class: Immunological agent, (Mab) HER2-I
    • RoA: IV
    • MOA: monoclonal antibody binds to HER2 protein to inhibit the growth of tumor cells
    • Indication: Metastatic breast cancer, HER2 overexpression
  19. Zyvox
    • Gen: Linezolid
    • Class: Antibiotic (RNA-I), Oxazolidinone
    • RoA: IV
    • MOA: inhibits ribosomal translation by binding to 23S of 50S RNA
    • Indication: Pneumonia, Vanco-resistant Enterococcus faecium infection, infection of skin
  20. Protonix
    • Gen: Pantoprazole Sodium
    • Class: PPI
    • RoA: Oral, IV
    • MOA: inhibits acid secretion by covalently binding the H/K ATPase pump
    • Indication: GERD, Zollinger-Ellison Syndrome, Gastric hypersecretion
Card Set
Top 20 Hospital Drugs
Brand to Generic with Class, RoA, MOA and Indication