Antidepressants mainly work on _________.
First choice for depression.
SSRI Used in treatment of:
- - Depression
- - Anxiety
- - Bipolar & Psychotic phases
- - Chronic pain
- - Migraines
- - Sleep Apnea
- - Eating and panic d/o
NRI (bupropion) - Wellbutrin
Antidepressants interact with ________ & __________.
norepinephrine and serotonin
Norepinephrine and serotonin do what?
Regulate mood, arousal, attention, and sensory processing appetite.
Nardil, Parnate and Marplan are what type of antidepressants?
Lethal with overdose.
May take 4-6 weeks to become effective.
TCA's block cholinergic receptors causing anticholinergic effects like:
dry mouth, constipation, urinary hesitance, dry nasal congestion, blurred near vision.
_____ dysfunction and ______ gain are common reasons for noncompliance.
Sexual dysfunction and weight gain
Anticholinergic effects on the CV system RESTRICTS use in who?
Has a low incidence of sedation and anticholinergic
In general causes HYPOtension leading to heart failure
MAOI's will cause HTN crisis if eaten with what?
MAOI's are dangerous if combined with other drugs.
MAOI's can be lethal if overdosed
What is the biggest concern with MAOI's?
Antidepressant drug of choice.
Common side affects of SSRI:
- - Sexual dysfunction
- - weight gain
- - insomnia
- - anxiety/agitation
Types of Tyramine Foods:
- - Aged CHEESE & MEATS
- - Fava beans, tofu, banana peel, OVERRIPE fruit, avocado
- - Tap beer & microbrewery beer
- - Sauerkraut and anything SOY
- - Yogurt, sour cream
- - Peanuts, Brewers yeast
- - Coffeinated coffee, tea, chocolate- Lasagna and pizza
May eat these typs of cheese:
- Cottage cheese
- Processed cheese slices
If eat foods high in tyramine while taking MAOI may cause HTN crisis.
Signs and symptoms of HTN crisis:
- - Occipital h/a
- - Nausea
- - Increase HR and BP
- - Flushed face
- - Feeling "full"
- - Palpitations & chest pain
- - Sweating, fever, nausea, vomiting
- - Dilated pupils
If having a HTN crisis what should you do?
DO NOT lie down!
- IM chlorporamazine
- IV phentoloamine
Results from taking MAOI and SSRI at the same time.
Signs and symptoms of Serotonin Syndrome
- - Agitation
- - Sweating
- - Fever
- - Tachycardia
- - Hypotension
- - Rigidity
- - Hyperreflexia
What do to if someone has Serotonin Syndrome?
Stop the medication.
Symptoms of serotonin syndrome may develop rapidly patient's may die before any intervention is taken.
SUICIDE WATCH increase in risk during what time?
First 1-3 weeks of starting medication
Highly suicidal clients may need a medication that has no risk of lethal overdose.
Once clients begin taking medication for depression, they often feel more energy which increases the risk of a successful suicide.