-
Antidepressants mainly work on _________.
serotonin
-
First choice for depression.
SSRI
-
SSRI Used in treatment of:
- - Depression
- - Anxiety
- - Bipolar & Psychotic phases
Also:
- - Chronic pain
- - Migraines
- - Sleep Apnea
- - Eating and panic d/o
-
Antidepressant Drugs:
SSRI
TCA
MAOI
NRI (bupropion) - Wellbutrin
SNRI
Heterocyclics
-
Antidepressants interact with ________ & __________.
norepinephrine and serotonin
-
Norepinephrine and serotonin do what?
Regulate mood, arousal, attention, and sensory processing appetite.
-
Nardil, Parnate and Marplan are what type of antidepressants?
MAOI
-
Lethal with overdose.
TCA
-
May take 4-6 weeks to become effective.
TCA's
-
TCA's block cholinergic receptors causing anticholinergic effects like:
dry mouth, constipation, urinary hesitance, dry nasal congestion, blurred near vision.
-
With TCA's:
_____ dysfunction and ______ gain are common reasons for noncompliance.
Sexual dysfunction and weight gain
-
With TCA's:
Anticholinergic effects on the CV system RESTRICTS use in who?
elderly
-
Has a low incidence of sedation and anticholinergic
MAOI
-
In general causes HYPOtension leading to heart failure
MAOI
-
MAOI's will cause HTN crisis if eaten with what?
tyramine
-
MAOI's are dangerous if combined with other drugs.
True.
-
MAOI's can be lethal if overdosed
-
What is the biggest concern with MAOI's?
HTN crisis.
-
Antidepressant drug of choice.
-
Common side affects of SSRI:
- - Sexual dysfunction
- - weight gain
- - insomnia
- - anxiety/agitation
-
Types of Tyramine Foods:
- - Aged CHEESE & MEATS
- - Fava beans, tofu, banana peel, OVERRIPE fruit, avocado
- - Tap beer & microbrewery beer
- - Sauerkraut and anything SOY
- - Yogurt, sour cream
- - Peanuts, Brewers yeast
- - Coffeinated coffee, tea, chocolate- Lasagna and pizza
-
May eat these typs of cheese:
- Cottage cheese
- Ricotta
- Processed cheese slices
-
If eat foods high in tyramine while taking MAOI may cause HTN crisis.
Signs and symptoms of HTN crisis:
- - Occipital h/a
- - Nausea
- - Increase HR and BP
- - Flushed face
- - Feeling "full"
- - Palpitations & chest pain
- - Sweating, fever, nausea, vomiting
- - Dilated pupils
-
If having a HTN crisis what should you do?
DO NOT lie down!
- IM chlorporamazine
- IV phentoloamine
-
Results from taking MAOI and SSRI at the same time.
Serotonin Syndrome
-
Signs and symptoms of Serotonin Syndrome
- - Agitation
- - Sweating
- - Fever
- - Tachycardia
- - Hypotension
- - Rigidity
- - Hyperreflexia
-
What do to if someone has Serotonin Syndrome?
Stop the medication.
Symptomatic treatment.
-
Symptoms of serotonin syndrome may develop rapidly patient's may die before any intervention is taken.
-
SUICIDE WATCH increase in risk during what time?
First 1-3 weeks of starting medication
-
Highly suicidal clients may need a medication that has no risk of lethal overdose.
Once clients begin taking medication for depression, they often feel more energy which increases the risk of a successful suicide.
|
|